Actigall: Effective Dissolution of Gallstones with Ursodiol
Actigall
| Product dosage: 150mg | |||
|---|---|---|---|
| Package (num) | Per tab | Price | Buy |
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| 60 | 2.15 $ | 140.40 $ 128.70 $ (8%) | 🛒 Add to cart |
| 90 | 1.92 $ | 210.60 $ 173.16 $ (18%) | 🛒 Add to cart |
| 120 | 1.82 $ | 280.80 $ 218.79 $ (22%) | 🛒 Add to cart |
| 180 | 1.72 $ | 421.20 $ 308.88 $ (27%) | 🛒 Add to cart |
| 360 | 1.61 $
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| Product dosage: 300mg | |||
|---|---|---|---|
| Package (num) | Per tab | Price | Buy |
| 30 | 4.68 $ | 140.40 $ (0%) | 🛒 Add to cart |
| 60 | 3.86 $ | 280.80 $ 231.66 $ (17%) | 🛒 Add to cart |
| 90 | 3.60 $ | 421.20 $ 324.09 $ (23%) | 🛒 Add to cart |
| 120 | 3.46 $ | 561.60 $ 415.35 $ (26%) | 🛒 Add to cart |
| 180 | 3.39 $
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Synonyms | |||
Actigall (ursodiol) is a prescription medication specifically formulated to dissolve certain types of gallstones in patients for whom surgery poses an unacceptable risk. It works by reducing the cholesterol saturation of bile, thereby promoting the gradual dissolution of cholesterol-rich gallstones. This therapeutic approach offers a non-surgical alternative for appropriately selected patients, providing a targeted medical intervention for a common and often painful condition.
Features
- Active ingredient: Ursodiol (ursodeoxycholic acid)
- Available in 300 mg capsules
- Hydrophilic bile acid that reduces cholesterol secretion into bile
- Increases the concentration of bile acids that solubilize cholesterol
- Formulated for oral administration
- Requires prescription and medical supervision
Benefits
- Provides a non-surgical alternative for gallstone treatment in eligible patients
- Effectively dissolves cholesterol gallstones over time
- Reduces the risk of gallstone-related complications
- May prevent formation of new gallstones in susceptible individuals
- Allows patients to avoid invasive surgical procedures
- Can improve digestive function and reduce biliary pain
Common use
Actigall is primarily indicated for the dissolution of radiolucent, non-calcified gallbladder stones less than 20 mm in diameter in patients with functioning gallbladders who are at high risk for cholecystectomy. It is also used to prevent gallstone formation in obese patients experiencing rapid weight loss. Additionally, Actigall finds application in the treatment of primary biliary cholangitis, where it helps improve liver enzyme levels and may slow disease progression.
Dosage and direction
For gallstone dissolution: The typical adult dosage is 8-10 mg/kg/day administered in two or three divided doses. Treatment usually continues for 6-24 months, with regular monitoring via ultrasound to assess stone dissolution. For primary biliary cholangitis: 13-15 mg/kg/day administered in two to four divided doses. Capsules should be taken with food to enhance absorption and minimize gastrointestinal discomfort. Dosage adjustments may be necessary based on patient response and tolerance.
Precautions
Patients should undergo thorough evaluation before starting Actigall therapy, including confirmation of cholesterol gallstones and assessment of gallbladder function. Regular monitoring of liver function tests is essential throughout treatment. Use with caution in patients with hepatic impairment, as dosage adjustments may be necessary. Patients should be advised that complete dissolution may not occur in all cases, and stones may recur after successful treatment. Pregnancy and breastfeeding require careful consideration of risks versus benefits.
Contraindications
Actigall is contraindicated in patients with radiopaque (calcified) gallstones, non-functioning gallbladders, or known hypersensitivity to ursodiol or any component of the formulation. It should not be used in patients with acute cholecystitis, cholangitis, biliary obstruction, or frequent biliary colic. Concomitant use with cholestyramine, colestipol, or aluminum-based antacids is contraindicated due to reduced absorption.
Possible side effects
Common side effects include diarrhea or loose stools (which often resolve with continued therapy), nausea, vomiting, dyspepsia, and abdominal discomfort. Less frequently reported effects include headache, dizziness, constipation, and hair thinning. Rare but serious side effects may include worsening liver function, allergic reactions, and calcification of remaining gallstones. Patients should report persistent or severe symptoms to their healthcare provider.
Drug interaction
Actigall may interact with several medications, including:
- Cholestyramine, colestipol, and aluminum-based antacids (reduce absorption)
- Estrogens and oral contraceptives (may promote gallstone formation)
- Cyclosporine (may affect blood levels)
- Clofibrate and other lipid-lowering agents
- Antacids containing aluminum hydroxide Patients should inform their healthcare provider about all medications, including over-the-counter drugs and supplements.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next scheduled dose. In that case, the missed dose should be skipped, and the regular dosing schedule resumed. Patients should not double the dose to make up for a missed one. Consistent daily dosing is important for optimal therapeutic effect.
Overdose
There are no reported cases of serious toxicity from ursodiol overdose. However, excessive doses may lead to severe diarrhea and gastrointestinal distress. In case of suspected overdose, symptomatic and supportive care is recommended. Patients should contact their healthcare provider or poison control center for guidance.
Storage
Store at room temperature (20-25°C or 68-77°F) in the original container. Protect from light and moisture. Keep tightly closed and out of reach of children. Do not use after the expiration date printed on the packaging. Do not transfer capsules to other containers, as this may affect stability.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Actigall should only be used under the supervision of a qualified healthcare professional. Patients should not initiate or discontinue treatment without consulting their physician. Individual results may vary, and proper diagnosis and monitoring are essential for safe and effective treatment.
Reviews
Clinical studies demonstrate that Actigall achieves complete gallstone dissolution in approximately 30-40% of appropriately selected patients after 6-24 months of therapy. Many patients report significant reduction in biliary symptoms within the first few months of treatment. Healthcare providers note the importance of proper patient selection and consistent follow-up for optimal outcomes. Some patients express satisfaction with avoiding surgery, while others note the extended treatment duration as a consideration.