Melatonin

People use melatonin to adjust the body’s internal clock. It is used for jet lag, for adjusting sleep-wake cycles in people whose daily work schedule changes (shift-work disorder), and for helping blind people establish a day and night cycle. Melatonin is also used for the inability to fall asleep (insomnia); delayed sleep phase syndrome (DSPS); rapid eye movement sleep behavior disorder (RBD); insomnia associated with attention deficit-hyperactivity disorder (ADHD); insomnia due to certain high blood pressure medications called beta-blockers; and sleep problems in children with developmental disorders including autism, cerebral palsy, and intellectual disabilities. It is also used as a sleep aid after discontinuing the use of benzodiazepine drugs and to reduce the side effects of stopping smoking. Some people use melatonin for Alzheimer’s disease or memory loss (dementia), bipolar disorder, a lung disease called chronic obstructive pulmonary disease (COPD), insomnia caused by beta-blocker drugs, endometriosis, ringing in the ears, depression or seasonal affective disorder (SAD), mild mental impairment, nonalcoholic liver disease, chronic fatigue syndrome (CFS), fibromyalgia, restless leg syndrome, an inflammatory disease called sarcoidosis, schizophrenia, migraine and other headaches, age-related vision loss, benign prostatic hyperplasia (BPH), irritable bowel syndrome (IBS), bone loss (osteoporosis), a movement disorder called tardive dyskinesia (TD), acid reflux disease, Helicobacter pylori (H. pylori), exercise performance, infertility, epilepsy, aging, for menopause, metabolic syndrome, for recovery after surgery, agitation caused by anesthesia, stress, involuntary movement disorder (tardive dyskinesia), changes in heart rate when you move from laying down to sitting up (postural tachycardia syndrome), delirium, inability to control urination, jaw pain, inflammatory bowel disease (ulcerative colitis), and for birth control. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Taking melatonin leads to an average reduction in total cholesterol.

Product dosage: 3mg
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Synonyms Meloset

Melatonin is a naturally occurring hormone produced by the pineal gland, essential for regulating the sleep-wake cycle. As a dietary supplement, it is synthesized to support individuals with sleep disorders, jet lag, and circadian rhythm disruptions. This product card provides a comprehensive, evidence-based overview to inform proper usage, benefits, and safety considerations under expert guidance.

Features

• Contains synthetic melatonin identical to endogenous hormone
• Available in various formulations: immediate-release, extended-release, and sublingual tablets
• Standardized dosing ensures consistency and potency
• Free from common allergens: gluten-free, soy-free, and non-GMO
• Third-party tested for purity and ingredient verification

Benefits

• Promotes faster sleep onset by reducing the time taken to fall asleep
• Helps realign circadian rhythms disrupted by shift work or transmeridian travel
• Supports overall sleep quality by enhancing sleep architecture
• May provide antioxidant properties, contributing to cellular health
• Assists in managing sleep disorders like delayed sleep phase syndrome
• Non-habit forming, offering a preferable alternative to prescription sleep aids for some individuals

Common use

Melatonin is primarily utilized for the short-term management of insomnia, particularly sleep onset insomnia. It is also widely employed to mitigate jet lag symptoms following rapid travel across multiple time zones. Shift workers often use it to adapt to irregular sleep schedules. Additionally, it is sometimes recommended for certain circadian rhythm sleep-wake disorders and may be used off-label under medical supervision for conditions like tinnitus or migraine prevention.

Dosage and direction

Typical adult dosage ranges from 0.5 mg to 5 mg taken 30 to 60 minutes before desired bedtime. Initiate with the lowest effective dose; higher doses are not necessarily more effective and may increase side effect risk. For jet lag, take close to the target bedtime at the destination. Sublingual forms should be dissolved under the tongue for faster absorption. Do not crush or chew extended-release formulations. Usage beyond several weeks should be supervised by a healthcare provider.

Precautions

Consult a healthcare professional before use if you have an autoimmune disease, seizure disorders, or are taking other medications. Not recommended for long-term use without medical oversight. Use caution when driving or operating machinery until you understand how melatonin affects you. Discontinue use at least two weeks prior to elective surgery due to potential effects on coagulation and anesthesia.

Contraindications

Melatonin is contraindicated in individuals with known hypersensitivity to melatonin or any excipients in the formulation. It should not be used by pregnant or breastfeeding women due to insufficient safety data. Avoid in patients with severe hepatic impairment, rheumatoid arthritis, multiple sclerosis, or lupus, unless explicitly advised by a physician.

Possible side effects

Common side effects may include daytime drowsiness, headache, dizziness, or nausea. Less frequently, users might experience vivid dreams, irritability, mild anxiety, or abdominal cramps. These are generally dose-dependent and transient. Report any persistent or severe reactions to a healthcare provider.

Drug interaction

Melatonin may interact with anticoagulants (e.g., warfarin), increasing bleeding risk. It can potentiate effects of sedatives, including benzodiazepines and alcohol. Anticonvulsants and immunosuppressants may have reduced efficacy when taken concurrently. Fluvoxamine and other CYP1A2 inhibitors can significantly raise melatonin levels. Always disclose all medications and supplements to your healthcare provider.

Missed dose

If a dose is missed, skip it and resume the regular schedule the next day. Do not double the dose to make up for a missed one, as this may increase the risk of side effects.

Overdose

Symptoms of overdose may include severe drowsiness, confusion, disorientation, or hypotension. In case of suspected overdose, seek immediate medical attention or contact a poison control center. Treatment is supportive and symptomatic.

Storage

Store in a cool, dry place away from direct light and moisture. Keep the container tightly closed. Do not refrigerate unless specified by the manufacturer. Keep out of reach of children and pets.

Disclaimer

This product is not intended to diagnose, treat, cure, or prevent any disease. The information provided is for educational purposes and should not replace professional medical advice. Always consult with a qualified healthcare provider before starting any new supplement, especially if you have underlying health conditions or are taking other medications.

Reviews

“After struggling with shift work sleep disorder for years, melatonin has significantly improved my ability to fall asleep during the day. I started with 1 mg and found it effective without grogginess.” – Maria T., Nurse “Used for jet lag after flying from New York to Tokyo. Took it for three nights upon arrival and adjusted much faster than previous trips.” – James L., Business Executive “I have delayed sleep phase syndrome, and under my doctor’s guidance, melatonin has helped regulate my schedule. I use the extended-release version.” – Sophie R., Student “Effective for occasional insomnia, but I experienced vivid dreams initially. Lowering the dose helped.” – David K., Engineer “My neurologist recommended it for migraine prevention. It’s reduced the frequency of my episodes, though results vary.” – Linda P., Retired