Benemid: Advanced Uric Acid Management for Gout Control
Benemid
| Product dosage: 500mg | |||
|---|---|---|---|
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| 90 | 0.81 $
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Synonyms | |||
Benemid (probenecid) is a well-established uricosuric agent specifically formulated to manage hyperuricemia associated with gout and gouty arthritis. By effectively increasing the urinary excretion of uric acid, it helps reduce serum urate levels, preventing the formation of tophi and decreasing the frequency of acute gout attacks. This medication is often used in combination with other agents to enhance therapeutic outcomes, providing a reliable option for long-term gout prophylaxis under medical supervision.
Features
- Active ingredient: Probenecid 500 mg
- Mechanism: Uricosuric agent that inhibits renal tubular reabsorption of uric acid
- Formulation: Oral tablets
- Prescription-only medication
- Compatible with penicillin and cephalosporin antibiotics to increase their plasma concentrations
Benefits
- Effectively lowers serum uric acid levels to prevent gout attacks
- Reduces formation of urate crystals and tophi in joints and tissues
- Decreases frequency and severity of acute gout episodes
- May be combined with colchicine or anti-inflammatory drugs for enhanced management
- Supports long-term gout prophylaxis when other treatments are insufficient
- Helps maintain joint function and mobility by preventing chronic arthropathy
Common use
Benemid is primarily indicated for the treatment of chronic gout and gouty arthritis in patients with underexcretion of uric acid. It is not intended for use during acute gout attacks but rather for prophylaxis to prevent recurrent episodes. The medication may also be prescribed as an adjunct to antibiotic therapy to elevate and prolong plasma concentrations of penicillin and cephalosporin derivatives.
Dosage and direction
The recommended adult dosage for gout management is 250 mg twice daily for one week, followed by 500 mg twice daily thereafter. Dosage may be increased by 500 mg every 4 weeks, if necessary, up to a maximum of 2-3 grams per day divided into two doses. For antibiotic adjunct therapy, typical dosing is 2 grams per day in divided doses. Benemid should be taken with food or antacids to minimize gastrointestinal discomfort. Maintain adequate hydration (8-10 glasses of fluid daily) to prevent uric acid kidney stone formation.
Precautions
Patients should be advised to avoid high-dose aspirin therapy while taking Benemid, as salicylates may diminish its uricosuric effect. Regular monitoring of serum uric acid levels and renal function is recommended. Use with caution in patients with history of peptic ulcer disease or blood dyscrasias. May cause false-positive results for glucose in urine using copper reduction methods. Not recommended for treatment of asymptomatic hyperuricemia.
Contraindications
Benemid is contraindicated in patients with known hypersensitivity to probenecid, children under 2 years of age, and patients with blood dyscrasias or uric acid kidney stones. Contraindicated in patients with acute gout attack (initiation should wait until acute inflammation subsides). Not recommended for patients with creatinine clearance less than 30 mL/min.
Possible side effect
Common side effects include gastrointestinal disturbances (nausea, vomiting, loss of appetite), headache, dizziness, and flushing. Less frequently, patients may experience urinary frequency, sore gums, hair loss, or skin rash. Rare but serious side effects include blood disorders, nephrotic syndrome, hepatic necrosis, and anaphylactic reactions. Immediately report any signs of bleeding, unusual fatigue, or yellowing of skin/eyes.
Drug interaction
Benemid interacts significantly with several medication classes. It prolongs half-life of penicillin, cephalosporins, and acyclovir. Concurrent use with methotrexate may increase methotrexate toxicity. Salicylates in high doses antagonize uricosuric effect. May increase concentrations of NSAIDs, sulfonylureas, and rifampin. Diuretics may decrease effectiveness of Benemid. Always inform healthcare providers of all medications being taken.
Missed dose
If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to make up for a missed one. Maintain regular dosing schedule to ensure consistent uric acid control. If multiple doses are missed, contact healthcare provider for guidance on resuming therapy.
Overdose
Symptoms of overdose may include nausea, vomiting, dizziness, and convulsions. In case of suspected overdose, seek immediate medical attention. Treatment is supportive and symptomatic. Maintain adequate urinary output and electrolyte balance. Hemodialysis may be effective in removing probenecid from circulation.
Storage
Store at room temperature (15-30°C/59-86°F) in a dry place protected from light and moisture. Keep in original container with lid tightly closed. Do not store in bathroom or near kitchen sink. Keep out of reach of children and pets. Properly discard any expired medication.
Disclaimer
This information is for educational purposes only and does not replace professional medical advice. Always consult with a qualified healthcare provider before starting or changing any treatment regimen. Individual results may vary based on health status and adherence to prescribed therapy. The manufacturer is not liable for any adverse outcomes resulting from improper use of this medication.
Reviews
Clinical studies demonstrate Benemid’s efficacy in maintaining serum uric acid levels below 6 mg/dL in approximately 70-80% of compliant patients. Many rheumatologists report satisfactory long-term results in gout prophylaxis, particularly when combined with appropriate lifestyle modifications. Some patients note gastrointestinal discomfort during initial treatment phase, which often resolves with continued use. Overall, Benemid remains a valuable option in the uricosuric class for appropriate patient populations.