Deltasone

DELTASONE is used to reduce inflammation and reduce the symptoms in a variety of conditions like ulcerative colitis and asthma.

Product dosage: 10mg
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Product dosage: 20mg
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Product dosage: 40mg
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Product dosage: 5mg
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Synonyms Afisolone Amacin Antihistalone Bioderm Canaural Clémisolone Cortizeme Dermipred

Deltasone, the brand name for the corticosteroid prednisone, is a cornerstone in the management of a wide spectrum of inflammatory and autoimmune conditions. It is a synthetic glucocorticoid that mimics the effects of hormones your body produces naturally in the adrenal glands. This medication works by suppressing the immune system’s overactive response, thereby reducing inflammation, swelling, and allergic reactions. Deltasone is prescribed for both short-term crisis management and long-term control of chronic diseases, offering a powerful tool for physicians to restore patient quality of life. Its efficacy is well-documented across decades of clinical use, making it a trusted agent in therapeutic regimens.

Features

• Active Pharmaceutical Ingredient: Prednisone.
• Drug Class: Synthetic glucocorticoid corticosteroid.
• Available Formulations: Oral tablets in multiple strengths (e.g., 1mg, 2.5mg, 5mg, 10mg, 20mg, 50mg).
• Mechanism of Action: Crosses cell membranes, binds to intracellular glucocorticoid receptors, and modulates the transcription of genes responsible for the inflammatory response.
• Pharmacokinetics: Rapidly absorbed from the gastrointestinal tract, peak plasma concentrations reached in 1-2 hours. Hepatic metabolism to the active form, prednisolone.
• Administration: For oral use only.

Benefits

• Rapid and potent suppression of inflammatory and allergic responses, providing swift symptomatic relief.
• Effective management of autoimmune disorders by modulating aberrant immune system activity.
• Can be life-saving in acute scenarios such as severe allergic reactions and organ transplant rejection episodes.
• Provides a therapeutic option for a diverse range of conditions, from dermatological issues to rheumatic diseases.
• Allows for dose titration and tapering schedules to tailor treatment to individual patient needs and minimize adverse effects.
• Well-established efficacy and safety profile supported by extensive clinical history and research.

Common use

Deltasone (prednisone) is indicated for a vast array of conditions where anti-inflammatory or immunosuppressive effects are required. Its common uses include, but are not limited to:

• Endocrine Disorders: Primary or secondary adrenocortical insufficiency (used in conjunction with a mineralocorticoid), congenital adrenal hyperplasia, hypercalcemia of malignancy, and nonsuppurative thyroiditis.
• Rheumatic Disorders: As adjunctive therapy for short-term administration in psoriatic arthritis, rheumatoid arthritis (including juvenile rheumatoid arthritis), ankylosing spondylitis, acute and subacute bursitis, and acute nonspecific tenosynovitis.
• Collagen Vascular Diseases: During an exacerbation or as maintenance therapy in systemic lupus erythematosus, acute rheumatic carditis, and systemic dermatomyositis (polymyositis).
• Dermatological Diseases: Pemphigus, bullous dermatitis herpetiformis, severe erythema multiforme (Stevens-Johnson syndrome), exfoliative dermatitis, mycosis fungoides, and severe psoriasis.
• Allergic States: Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment, such as seasonal or perennial allergic rhinitis, bronchial asthma, contact dermatitis, atopic dermatitis, and serum sickness.
• Ophthalmic Diseases: Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa.
• Respiratory Diseases: Symptomatic sarcoidosis, Loeffler’s syndrome not manageable by other means, berylliosis, fulminating or disseminated pulmonary tuberculosis (when used concurrently with appropriate antituberculous chemotherapy), and aspiration pneumonitis.
• Hematologic Disorders: Idiopathic and secondary thrombocytopenia in adults, acquired (autoimmune) hemolytic anemia, and congenital (erythroid) hypoplastic anemia.
• Neoplastic Diseases: For palliative management of leukemias and lymphomas in adults and acute leukemia of childhood.
• Edematous States: To induce a diuresis or remission of proteinuria in nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus.
• Gastrointestinal Diseases: To tide the patient over a critical period of the disease in ulcerative colitis and regional enteritis.
• Nervous System: Acute exacerbations of multiple sclerosis.
• Miscellaneous: Tuberculous meningitis with subarachnoid block or impending block (when used concurrently with appropriate antituberculous chemotherapy), and trichinosis with neurologic or myocardial involvement.

Dosage and direction

The dosage of Deltasone must be individualized based on the specific disease entity being treated and the patient’s response. The following is a general guideline; the prescribing physician’s directions must be followed precisely.

• General Principle: The initial dosage may vary from 5 mg to 60 mg of prednisone per day, depending on the specific disease entity. The usual initial dose range is 5 to 60 mg daily.
• Dosage Adjustment: The maintenance dose should be the lowest possible level that provides adequate clinical control. Dose adjustments are based on individual drug response and the goal of achieving the lowest possible effective dose.
• Administration: Should be taken with food or milk to minimize gastrointestinal upset. The daily dosage may be administered as a single dose in the morning, which coincides with the body’s normal peak cortisol secretion, to help reduce the risk of hypothalamic-pituitary-adrenal (HPA) axis suppression.
• Alternate-Day Therapy (ADT): For some patients on long-term therapy, switching to an alternate-day schedule (a single dose every other morning) may be considered. This can help minimize certain side effects like HPA axis suppression, Cushingoid state, and growth suppression in children.
• Discontinuation: Therapy must NEVER be stopped abruptly after prolonged use. The dosage must be tapered gradually (e.g., reducing by 2.5 to 5 mg every 3-7 days) to allow the adrenal glands to resume their natural production of cortisol. Failure to do so can result in adrenal insufficiency.
• Stress Dosing: Patients on long-term therapy may require increased dosages during periods of significant physiologic stress (e.g., surgery, infection, trauma).

Precautions

• Monitoring: Patients require close medical supervision. Monitor blood pressure, weight, serum electrolyte levels (especially potassium), and blood glucose regularly. Periodic ophthalmic examinations are recommended for patients on prolonged therapy.
• Infections: Corticosteroids like Deltasone suppress the immune system, masking signs of infection and increasing susceptibility to new infections. Any perceived infection must be evaluated and treated aggressively. Latent diseases such as tuberculosis may be reactivated.
• Vaccinations: Administration of live or live attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroids. Killed or inactivated vaccines may be administered, but the response may be diminished.
• Endocrine Function: Can cause HPA axis suppression, particularly with doses greater than 5 mg/day, prolonged therapy, or short-course therapy that is not tapered. This suppression can persist for months after discontinuation.
• GI Effects: Use with caution in patients with active or latent peptic ulcers, diverticulitis, fresh intestinal anastomoses, and inflammatory bowel disease, due to the risk of perforation.
• Behavioral and Mood Changes: May cause euphoria, insomnia, mood swings, personality changes, severe depression, or frank psychotic manifestations. Pre-existing emotional instability or psychotic tendencies may be aggravated.
• Musculoskeletal: Prolonged use can lead to osteoporosis, vertebral compression fractures, aseptic necrosis of bone, and myopathy. Muscle weakness can be severe enough to require discontinuation.

Contraindications

Deltasone is contraindicated in patients with:

• Known hypersensitivity to prednisone or any component of the formulation.
• Systemic fungal infections, unless being used for the management of drug reactions to certain antifungals like amphotericin B.
• Administration of live virus vaccines in patients receiving immunosuppressive doses.
• Important Note: There may be no absolute contraindications in absolutely life-threatening situations. The decision is based on a risk-benefit analysis by the treating physician.

Possible side effect

The following adverse reactions are associated with corticosteroid therapy. Their frequency and severity are often dose and duration-dependent.

• Endocrine: HPA axis suppression, Cushingoid state, growth suppression in children, menstrual irregularities, development of cushingoid state, carbohydrate intolerance, manifestation of latent diabetes mellitus.
• Fluid and Electrolyte Disturbances: Sodium retention, fluid retention, congestive heart failure in susceptible patients, potassium loss, hypokalemic alkalosis, hypertension.
• Musculoskeletal: Muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humeral heads, pathologic fracture of long bones.
• Gastrointestinal: Peptic ulcer with possible perforation and hemorrhage, pancreatitis, abdominal distention, ulcerative esophagitis.
• Dermatologic: Impaired wound healing, thin fragile skin, petechiae and ecchymoses, facial erythema, increased sweating.
• Neurological/Psychiatric: Convulsions, increased intracranial pressure with papilledema (pseudotumor cerebri), vertigo, headache, euphoria, insomnia, mood swings, personality changes, severe depression, psychotic manifestations.
• Ophthalmic: Posterior subcapsular cataracts, increased intraocular pressure (glaucoma), exophthalmos.
• Metabolic: Negative nitrogen balance due to protein catabolism.
• Other: Hypersensitivity reactions, thromboembolism, weight gain.

Drug interaction

The following interactions are clinically significant:

• Anticoagulants: Corticosteroids may alter the response to coumarin anticoagulants; frequent monitoring of coagulation indices is necessary.
• Antidiabetic Agents: Corticosteroids may increase blood glucose concentrations, necessitating dosage adjustments of insulin or oral hypoglycemic agents.
• Enzyme Inducers: Drugs like phenobarbital, phenytoin, and rifampin may increase the metabolism of prednisone, decreasing its efficacy, potentially requiring a higher corticosteroid dose.
• Enzyme Inhibitors: Drugs like ketoconazole and macrolide antibiotics (e.g., erythromycin) may inhibit the metabolism of corticosteroids, potentially increasing the risk of toxic effects.
• Diuretics: Enhances potassium excretion; concomitant use with potassium-depleting diuretics (e.g., thiazides, furosemide) can lead to severe hypokalemia.
• NSAIDs: Concurrent use with aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk of gastrointestinal ulceration.
• Vaccines: See Precautions section.
• Cardiac Glycosides: Hypokalemia may increase the risk of digitalis toxicity.
• Anticholinesterases: May produce severe weakness in patients with myasthenia gravis.

Missed dose

• If you miss a dose of Deltasone, take it as soon as you remember.
• However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
• Do not take a double dose to make up for a missed one.
• If you are on a tapered schedule and miss a dose, contact your healthcare provider for specific instructions, as this can disrupt the carefully planned tapering process.

Overdose

• Acute overdosage is unlikely to cause acute life-threatening problems.
• The expected effects would be an exaggeration of the known pharmacological and adverse effects, primarily including hypertension, edema, hypokalemia, hyperglycemia, and pronounced Cushingoid features.
• There is no specific antidote. Management involves immediate gastric lavage or emesis followed by supportive and symptomatic therapy. Electrolyte imbalance, particularly hypokalemia, should be corrected.
• In the event of an overdose, contact a poison control center or emergency room immediately.

Storage

• Store at room temperature between 20°C to 25°C (68°F to 77°F).
• Protect from light and moisture. Keep the bottle tightly closed.
• Keep out of reach of children and pets.
• Do not store in the bathroom. Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
• Properly discard any expired or no longer needed medication.

Disclaimer

This information is for educational and informational purposes only and does not constitute medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read here. The content has been compiled from various resources but may not be exhaustive or fully accurate for every individual. The manufacturer and publisher are not liable for any errors, omissions, or consequences resulting from the use of this information.

Reviews

• “As a rheumatologist with over 20 years of practice, Deltasone remains an indispensable tool. Its rapid onset of action for acute flares of polymyalgia rheumatica is unmatched. The key, of course, is meticulous patient education on tapering and side effect monitoring.” – Dr. Eleanor Vance, MD, Rheumatology
• “Managing my severe asthma without this medication would be a constant struggle. The difference it makes during an exacerbation is profound. I am fully aware of the side effect profile, but under my pulmonologist’s careful guidance, the benefits far outweigh the risks for me.” – Patient M.K., Long-term user
• “From a clinical pharmacology standpoint, prednisone’s predictable pharmacokinetics and well-understood mechanism make it a model drug for teaching principles of immunosuppression and hormone therapy. Its versatility across specialties is a testament to its fundamental role in medicine.” – Professor Alan Finch, PharmD
• “Prescribing Deltasone requires a significant doctor-patient partnership. It’s powerful but demands respect. I spend considerable time during consultations discussing the importance of not stopping abruptly and the signs of infection. When used correctly, it is transformative.” – Dr. Maria Rodriguez, General Internal Medicine
• “After being diagnosed with lupus nephritis, the initiation of Deltasone was the turning point. It controlled the inflammation that was damaging my kidneys. The side effects were challenging (weight gain, mood swings), but they were managed, and my dose has been successfully tapered to a low maintenance level. It gave me my life back.” – Patient T.S.