Dutas

Dutas prevents the conversion of testosterone to dihydrotestosterone (DHT) in the body. DHT is involved in the development of benign prostatic hyperplasia (BPH).

Product dosage: 0.5mg
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Dutas is a prescription medication specifically formulated for the management of symptomatic benign prostatic hyperplasia (BPH). It combines two active ingredients, dutasteride and tamsulosin, to provide a dual mechanism of action that addresses both the static and dynamic components of prostate enlargement. This comprehensive approach helps reduce urinary symptoms, improve flow rate, and decrease the risk of acute urinary retention and the need for surgery. Clinically proven and widely prescribed, Dutas offers a reliable solution for men seeking long-term control over BPH-related discomfort and complications.

Features

• Contains dutasteride 0.5 mg and tamsulosin hydrochloride 0.4 mg per capsule
• Dual 5-alpha-reductase inhibitor and alpha-1 adrenergic blocker
• Gelatin-based, opaque white and blue capsules for easy identification
• Available in blister packs of 10 capsules
• Requires prescription and medical supervision
• Manufactured under strict pharmaceutical quality standards

Benefits

• Significantly improves urinary flow and reduces hesitancy
• Decreases prostate volume over time, addressing the underlying cause of BPH
• Lowers the risk of acute urinary retention and BPH-related surgery
• Provides relief from bothersome symptoms such as nocturia, urgency, and incomplete emptying
• Enhances overall quality of life by reducing urinary discomfort and inconvenience
• Offers a convenient once-daily dosing regimen for consistent therapeutic effect

Common use

Dutas is primarily indicated for the treatment of signs and symptoms of benign prostatic hyperplasia in men with an enlarged prostate. It is suitable for patients who present with moderate to severe urinary symptoms, including weak stream, straining, frequency, and urgency. The medication is intended for long-term use, as therapeutic benefits, particularly those related to prostate size reduction, develop gradually over several months. It is not approved for use in women or children.

Dosage and direction

The recommended dosage of Dutas is one capsule (0.5 mg dutasteride/0.4 mg tamsulosin) taken orally once daily, approximately 30 minutes after the same meal each day to ensure consistent absorption. Swallow the capsule whole; do not crush, chew, or open it. It may take up to 6 months of continuous therapy to achieve maximum symptomatic improvement. Dosage adjustment is not typically required for elderly patients, but those with severe renal or hepatic impairment should use Dutas with caution and under close medical supervision.

Precautions

• Not for use by women, especially those who are or may become pregnant, due to risk of fetal harm
• May cause dizziness or drowsiness; caution advised when driving or operating machinery
• Patients should be monitored periodically for prostate cancer, as Dutas may lower PSA levels
• Avoid in patients with a history of orthostatic hypotension or severe liver impairment
• Use with caution in those taking strong CYP3A4 inhibitors or other alpha-blockers
• Inform healthcare provider of all current medications, including over-the-counter drugs and supplements

Contraindications

• Hypersensitivity to dutasteride, tamsulosin, other 5-alpha-reductase inhibitors, or any component of the formulation
• History of severe hepatic impairment
• Concomitant use with other alpha-adrenergic blocking agents
• Use in women and children
• Patients with a history of priapism or conditions that predispose to priapism

Possible side effect

Common side effects may include:

• Ejaculation disorders (e.g., decreased ejaculate volume)
• Impotence
• Libido decrease
• Dizziness
• Orthostatic hypotension

Less common side effects:

• Testicular pain and swelling
• Breast enlargement or tenderness
• Rhinitis
• Insomnia
• Blurred vision

Rare but serious side effects:

• Allergic reactions (rash, itching, swelling)
• Priapism (prolonged and painful erection)
• Severe dizziness or fainting
• Intraoperative floppy iris syndrome (IFIS) during cataract surgery

Drug interaction

• Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) may increase dutasteride exposure
• Other alpha-adrenergic blockers may potentiate hypotensive effects
• PDE5 inhibitors (e.g., sildenafil) may enhance blood pressure-lowering effects
• Warfarin: monitor INR closely as tamsulosin may affect protein binding
• Cimetidine may reduce the metabolism of tamsulosin

Missed dose

If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for the missed one. Resume the regular dosing schedule. Consistent daily use is important for optimal therapeutic effect.

Overdose

In case of overdose, supportive and symptomatic treatment is recommended. Potential effects may include severe dizziness, fainting, tachycardia, or hypotension. Dialysis is not likely to be effective due to high protein binding. Contact a poison control center or seek immediate medical attention.

Storage

Store at room temperature (15-30°C), in a dry place, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

“Dutas has significantly improved my quality of life. After six months of use, my urinary symptoms have reduced dramatically, and I no longer wake up multiple times at night.” – James L., 68

“As a urologist, I have prescribed Dutas to numerous patients with excellent results. The combination therapy offers a robust approach to managing BPH, with most men experiencing noticeable improvement within 3-6 months.” – Dr. A. Sharma, MD

“Initially experienced some dizziness, but it subsided after two weeks. Now, a year in, my flow is better, and my PSA levels have stabilized. Highly effective with consistent use.” – Robert T., 71