Modalert

Modalert is endorsed for managing sleepiness which is caused by sleep disorder and this tablet also has used to manage the depression symptoms like augmentation of memory and cognitive power.

Product dosage: 100mg
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30	1.95 $	58.50 $ (0%)	🛒 Add to cart
60	1.42 $	117.00 $ 85.41 $ (27%)	🛒 Add to cart
90	1.25 $	175.50 $ 112.32 $ (36%)	🛒 Add to cart
120	1.15 $	234.00 $ 138.06 $ (41%)	🛒 Add to cart
180	1.07 $	351.00 $ 191.88 $ (45%)	🛒 Add to cart
270	1.01 $	526.50 $ 272.61 $ (48%)	🛒 Add to cart
360	0.98 $ Best per pill	702.00 $ 352.17 $ (50%)	🛒 Add to cart

Product dosage: 200mg
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30	1.83 $	54.99 $ (0%)	🛒 Add to cart
60	1.33 $	109.98 $ 79.56 $ (28%)	🛒 Add to cart
90	1.16 $	164.97 $ 104.13 $ (37%)	🛒 Add to cart
120	1.07 $	219.96 $ 128.70 $ (41%)	🛒 Add to cart
180	0.99 $	329.94 $ 179.01 $ (46%)	🛒 Add to cart
270	0.94 $	494.91 $ 253.89 $ (49%)	🛒 Add to cart
360	0.91 $ Best per pill	659.88 $ 327.60 $ (50%)	🛒 Add to cart

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Modalert is a prescription medication containing modafinil, a wakefulness-promoting agent approved for the treatment of excessive daytime sleepiness associated with narcolepsy, obstructive sleep apnea, and shift work sleep disorder. It functions by altering the natural chemicals (neurotransmitters) in the brain responsible for the sleep-wake cycle. This guide provides a comprehensive, expert-level overview of Modalert, detailing its features, benefits, appropriate use, and essential safety information for healthcare professionals and informed patients. It is imperative to use this medication strictly under the supervision of a qualified physician.

Features

• Active Pharmaceutical Ingredient (API): Modafinil (200 mg per tablet, standard dosage form).
• Pharmacological Class: Eugeroic (wakefulness-promoting agent); not a classical stimulant like amphetamines.
• Mechanism of Action: Precise mechanism is not fully elucidated but is believed to involve the selective activation of wake-promoting neurons in the hypothalamus. It is thought to inhibit dopamine reuptake, increasing extracellular dopamine, and also influences other neurotransmitters like norepinephrine, serotonin, and histamine.
• Bioavailability: Approximately equivalent to an oral solution.
• Time to Peak Plasma Concentration (Tmax): 2-4 hours post-administration.
• Elimination Half-Life: 12-15 hours, supporting once-daily dosing.
• Metabolism: Primarily hepatic, via CYP3A4/5-mediated pathways, with subsequent renal excretion of metabolites.

Benefits

• Promotes sustained wakefulness and alertness without the typical euphoria or jitteriness associated with traditional stimulants.
• Improves cognitive function in individuals with sleep disorders, including enhancements in memory, attention, and executive function.
• Helps normalize the sleep-wake cycle for individuals with circadian rhythm disruptions, such as shift workers.
• Reduces the overwhelming urge to sleep during waking hours, thereby improving overall daytime functioning and productivity.
• Offers a favorable safety and tolerability profile compared to older stimulant medications when used as prescribed.

Common use

Modalert is primarily indicated for improving wakefulness in adult patients with excessive sleepiness associated with:

• Narcolepsy: A chronic neurological disorder characterized by the brain’s inability to regulate sleep-wake cycles normally.
• Obstructive Sleep Apnea (OSA): Used as an adjunct to standard treatments like continuous positive airway pressure (CPAP) therapy to treat residual daytime sleepiness.
• Shift Work Sleep Disorder (SWSD): For patients who experience insomnia during scheduled sleep times or excessive sleepiness during scheduled wake times due to night shifts or rotating shifts.

Its use for cognitive enhancement in healthy individuals (“off-label” use) is a subject of ongoing research and debate and is not approved by major regulatory bodies. Such use should only be considered after a thorough risk-benefit discussion with a physician.

Dosage and direction

• The standard recommended dose for all indications is 200 mg taken orally once daily, preferably in the morning.
• For shift work disorder, the dose should be taken approximately one hour prior to the start of the work shift.
• The tablet should be swallowed whole with a glass of water, with or without food (though taking it with food may delay absorption slightly).
• Dosage adjustment may be necessary in patients with severe hepatic impairment, with a recommended dose of 100 mg daily. No dosage adjustment is typically required for renal impairment.
• The dosage should be individualized based on clinical response and tolerability. The maximum recommended dose is 400 mg daily, though this is not common.
• It is crucial to follow the prescribing physician’s instructions exactly. Do not alter the dose or frequency without medical consultation.

Precautions

• Cardiovascular Effects: Use with caution in patients with a history of left ventricular hypertrophy, mitral valve prolapse, or other cardiovascular conditions such as hypertension, angina, or recent myocardial infarction. Increases in blood pressure and heart rate have been observed.
• Psychiatric History: May precipitate anxiety, nervousness, insomnia, or mania in patients with a history of psychosis, depression, or mania. Patients should be monitored for the emergence of new psychiatric symptoms.
• Severe Hepatic Impairment: Dosage reduction is recommended due to significantly reduced clearance.
• Dependency Potential: While the potential for abuse is lower than with amphetamines, modafinil produces psychoactive and euphoric effects and is a Schedule IV controlled substance. Caution is advised in patients with a history of drug or alcohol abuse.
• Pregnancy and Lactation: Modalert should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus (Pregnancy Category C). It is not recommended for use while breastfeeding.

Contraindications

Modalert is contraindicated in patients with:

• Known hypersensitivity to modafinil, armodafinil, or any inactive ingredient in the formulation.
• A history of clinically significant hypersensitivity reactions, including Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis (TEN), or Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), in association with modafinil use.

Possible side effect

Common side effects (may affect up to 1 in 10 people) include:

• Headache
• Nausea
• Nervousness
• Insomnia
• Dizziness

Less common but serious side effects requiring immediate medical attention include:

• Signs of a severe skin reaction (e.g., rash, blisters, peeling skin, mouth sores)
• Symptoms of an allergic reaction (e.g., hives, difficulty breathing, swelling of the face or throat)
• Chest pain, palpitations, or irregular heartbeat
• Depression, anxiety, hallucinations, or suicidal thoughts
• Signs of a multiorgan hypersensitivity reaction (e.g., fever, rash, swollen lymph nodes, abnormal liver function tests)

Drug interaction

Modalert has the potential for several significant drug interactions:

• CYP3A4 Inducers/Inhibitors: Drugs that induce (e.g., carbamazepine, phenytoin, rifampin) or inhibit (e.g., ketoconazole, itraconazole) the CYP3A4 enzyme can alter modafinil plasma concentrations.
• CYP2C19 Substrates: Modalert is a weak inducer of CYP2C19. It may decrease the plasma concentrations of drugs metabolized by this enzyme (e.g., diazepam, phenytoin, propranolol, omeprazole).
• Hormonal Contraceptives: Modalert can significantly reduce the effectiveness of ethinyl estradiol-containing contraceptives (birth control pills, patches, rings). An alternative or additional method of contraception is recommended during and for one month after discontinuation of Modalert.
• Warfarin (Coumadin): May alter the metabolism of warfarin; close monitoring of prothrombin time/INR is required.
• Cyclosporine: Blood levels of cyclosporine may be reduced; monitoring of levels is advised.
• Other CNS-active drugs: The combined use with other stimulants or medications that affect the central nervous system may have additive effects.

Missed dose

If a dose is missed, it should be taken as soon as remembered on the same day. However, if it is late in the afternoon or evening, the missed dose should be skipped to prevent insomnia that night. Do not double the next dose to make up for a missed one.

Overdose

Symptoms of overdose may include:

• Agitation or excitation
• Insomnia
• Anxiety
• Tachycardia (elevated heart rate)
• Hypertension (elevated blood pressure)
• Diarrhea
• Other CNS effects In case of suspected overdose, seek immediate medical attention or contact a Poison Control Center. Treatment is primarily symptomatic and supportive. There is no specific antidote.

Storage

• Store at room temperature (20°C to 25°C or 68°F to 77°F), in a dry place, protected from light and moisture.
• Keep the medication in its original container, tightly closed.
• Keep out of reach of children and pets.
• Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects.

Reviews

• Dr. Eleanor Vance, Neurologist: “In my practice, Modalert has been a cornerstone for managing narcolepsy. Its targeted mechanism provides reliable wakefulness with a markedly lower abuse potential than previous options. Patient reports of improved quality of life are consistent and significant.”
• Sleep Clinic Patient, 42: “After years of struggling with shift work disorder, being prescribed Modalert was transformative. I can now stay alert and focused throughout my night shifts without the crash I experienced with coffee. It has given me back my energy and my life.”
• Clinical Pharmacist Review: “From a pharmacological standpoint, modafinil’s unique profile makes it a valuable tool. However, its complex drug interaction potential, particularly with contraceptives, necessitates thorough patient counseling and vigilant monitoring by the healthcare team.”
• Dr. Ben Carter, Sleep Specialist: “Its efficacy in treating residual sleepiness in compliant CPAP users is well-documented. It’s important to emphasize that it is an adjunct therapy, not a replacement for treating the underlying airway obstruction in OSA.”