Motilium: Effective Relief from Nausea and Digestive Discomfort
Motilium
| Product dosage: 10mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | 4.68 $ | 46.80 $ (0%) | 🛒 Add to cart |
| 20 | 2.63 $ | 93.60 $ 52.65 $ (44%) | 🛒 Add to cart |
| 30 | 1.95 $ | 140.40 $ 58.50 $ (58%) | 🛒 Add to cart |
| 60 | 1.07 $ | 280.80 $ 64.35 $ (77%) | 🛒 Add to cart |
| 90 | 0.78 $ | 421.20 $ 70.20 $ (83%) | 🛒 Add to cart |
| 120 | 0.63 $ | 561.60 $ 76.05 $ (86%) | 🛒 Add to cart |
| 180 | 0.45 $ | 842.40 $ 81.90 $ (90%) | 🛒 Add to cart |
| 270 | 0.37 $ | 1263.60 $ 99.45 $ (92%) | 🛒 Add to cart |
| 360 | 0.31 $
Best per pill | 1684.80 $ 111.15 $ (93%) | 🛒 Add to cart |
Synonyms
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Motilium (domperidone) is a trusted, doctor-recommended medication designed to provide rapid and effective relief from symptoms of nausea and vomiting. It works by blocking dopamine receptors in the brain and upper digestive tract, which helps to normalize stomach emptying and reduce feelings of sickness. This makes it a first-line choice for managing a range of gastrointestinal motility disorders, offering patients a return to comfort and daily normalcy.
Features
- Active ingredient: Domperidone
- Available in 10 mg tablets and suspension forms
- Dopamine D2 and D3 receptor antagonist
- Promotes coordinated peristalsis in the upper GI tract
- Rapid absorption with onset of action typically within 30–60 minutes
Benefits
- Quickly alleviates episodes of nausea and vomiting
- Restores normal digestive rhythm, reducing bloating and fullness
- Enables comfortable eating and drinking during illness or recovery
- Supports management of chronic conditions like diabetic gastroparesis
- Minimizes disruption to daily activities and improves quality of life
- Trusted in clinical practice for its favorable safety profile when used as directed
Common use
Motilium is commonly prescribed for the short-term treatment of nausea and vomiting, particularly when these symptoms are associated with delayed gastric emptying. It is also used off-label in some regions to stimulate lactation in breastfeeding women, though this application should only be pursued under strict medical supervision. Patients with functional dyspepsia, gastroparesis, or those undergoing chemotherapy may also benefit from its prokinetic effects.
Dosage and direction
For adults and adolescents 12 years and older weighing 35 kg or more, the typical dosage is one 10 mg tablet taken 3–4 times daily, preferably 15–30 minutes before meals and at bedtime. The maximum daily dose should not exceed 30 mg. For suspension forms, always use the measuring device provided to ensure accurate dosing. Treatment duration should be as short as possible and reviewed regularly by a healthcare provider. Use in children under 12 or those weighing less than 35 kg requires careful medical assessment and dose adjustment.
Precautions
Patients with pre-existing liver impairment should use Motilium with caution and may require dose adjustments. Electrolyte disturbances, particularly hypokalemia or hypomagnesemia, should be corrected before initiation. Use in elderly patients may require careful monitoring due to increased risk of certain adverse effects, including QT prolongation. Avoid concomitant use with other QT-prolonging drugs. Patients should be advised not to exceed the recommended dose or duration of therapy.
Contraindications
Motilium is contraindicated in patients with known hypersensitivity to domperidone or any excipients in the formulation. It must not be used in individuals with moderate or severe hepatic impairment, pre-existing cardiac conditions such as congestive heart failure, or those with a history of ventricular arrhythmia. Concomitant use with strong CYP3A4 inhibitors is contraindicated. It should not be used when gastrointestinal obstruction or perforation is suspected.
Possible side effect
Common side effects may include dry mouth, headache, and abdominal cramps. Less frequently, patients may experience nervousness, drowsiness, or diarrhea. Although rare, serious side effects such as extrapyramidal symptoms (e.g., involuntary movements), hyperprolactinemia leading to galactorrhea or gynecomastia, and QT interval prolongation have been reported. Any signs of irregular heartbeat or allergic reaction warrant immediate medical attention.
Drug interaction
Motilium is metabolized primarily by CYP3A4; concomitant use with strong inhibitors of this enzyme (e.g., ketoconazole, erythromycin, ritonavir) is contraindicated due to significantly increased domperidone levels and risk of QT prolongation. Use with other drugs that prolong the QT interval should be avoided. Anticholinergic agents may antagonize the prokinetic effects of domperidone. Always inform your healthcare provider of all medications, including over-the-counter drugs and supplements.
Missed dose
If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to make up for a missed one. Resume the regular dosing schedule. Consistent timing optimizes therapeutic effect, but occasional missed doses are unlikely to significantly impact treatment efficacy.
Overdose
Symptoms of overdose may include drowsiness, disorientation, and extrapyramidal reactions. In cases of significant overdose, QT prolongation and arrhythmias could occur. There is no specific antidote; treatment is supportive and symptomatic. Gastric lavage and administration of activated charcoal may be considered if ingestion was recent. Cardiac monitoring is advised in suspected overdose situations. Seek immediate medical assistance or contact a poison control center.
Storage
Store Motilium tablets or suspension at room temperature (15–30°C), in the original container, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. For suspension, discard any unused portion after 14 days of opening.
Disclaimer
This information is intended for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any new medication, especially if you have underlying health conditions or are taking other drugs. Dosage and suitability vary by individual; never self-prescribe or share medication.
Reviews
Clinical studies and patient reports consistently highlight Motilium’s efficacy in managing nausea and vomiting, with many users noting rapid symptom relief. Healthcare professionals value its role in supportive care, particularly in oncology and gastroenterology. Some reviews caution regarding its use in patients with specific cardiac risk factors, reinforcing the importance of medical supervision. Overall, it remains a well-regarded option within its indicated uses.