Motrin

Motrin is a nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.

Product dosage: 400mg
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Product dosage: 600mg
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Motrin is a trusted nonsteroidal anti-inflammatory drug (NSAID) containing ibuprofen as its active ingredient. It is widely utilized in both clinical and over-the-counter settings for its potent analgesic, anti-inflammatory, and antipyretic properties. Healthcare professionals frequently recommend Motrin for a range of conditions due to its well-established efficacy and safety profile when used as directed. This product card provides a comprehensive, evidence-based overview intended for informed use.

Features

• Active ingredient: Ibuprofen (200 mg per tablet in OTC strength; prescription strengths available)
• Drug class: Nonsteroidal anti-inflammatory drug (NSAID)
• Formulations: Coated tablets, caplets, liquid-filled capsules, oral suspension, chewable tablets
• Onset of action: Approximately 30 minutes
• Duration of effect: 4 to 6 hours per dose
• Available over-the-counter and by prescription

Benefits

• Provides rapid relief from mild to moderate pain, including headaches, dental pain, and muscular aches.
• Reduces inflammation associated with conditions such as arthritis, sprains, and tendonitis.
• Effectively lowers fever in adults and children.
• Improves mobility and comfort by alleviating joint stiffness and swelling.
• Offers flexible dosing options suitable for a wide age range when appropriate formulations are selected.
• Supported by extensive clinical research demonstrating its efficacy and tolerability.

Common use

Motrin is commonly used for the temporary relief of minor aches and pains due to the common cold, headache, toothache, backache, menstrual cramps, or minor injury. It is also indicated for the reduction of fever. For inflammatory conditions, such as rheumatoid arthritis or osteoarthritis, it is used to relieve signs and symptoms like swelling, stiffness, and joint pain. Always use the smallest effective dose for the shortest duration consistent with individual patient treatment goals.

Dosage and direction

For adults and children 12 years and older: The usual dose for pain/fever is 200–400 mg orally every 4 to 6 hours as needed. Do not exceed 1200 mg in 24 hours unless directed by a physician. For anti-inflammatory effects, doses may be higher and should be determined by a healthcare provider.
For children under 12: Use only as directed by a physician, based on weight and age. Typically, 5–10 mg/kg per dose every 6–8 hours, not to exceed 40 mg/kg/day.
Take with food or milk to minimize gastrointestinal upset. Swallow tablets whole with a full glass of water; do not crush, chew, or break unless formulated as chewable. Do not lie down for at least 10 minutes after taking.

Precautions

• Use with caution in patients with a history of gastrointestinal ulceration or bleeding.
• Avoid concomitant use with other NSAIDs or aspirin, as this increases risk of adverse effects.
• Monitor renal function in patients with pre-existing renal impairment, dehydration, or heart failure.
• May cause dizziness or drowsiness; use caution when operating machinery or driving.
• Long-term use should be supervised by a healthcare professional to monitor for potential hepatic, renal, or cardiovascular effects.
• Not recommended during the third trimester of pregnancy.

Contraindications

• Hypersensitivity to ibuprofen, aspirin, or other NSAIDs.
• History of asthma, urticaria, or other allergic-type reactions after taking aspirin or NSAIDs.
• Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
• Active peptic ulcer disease or gastrointestinal bleeding.
• Severe renal impairment or advanced kidney disease.
• Third trimester of pregnancy.

Possible side effect

Common side effects may include nausea, epigastric pain, heartburn, dizziness, or headache. Less frequently, rash, tinnitus, fluid retention, or elevated blood pressure may occur. Serious side effects, though rare, can include gastrointestinal bleeding, hepatotoxicity, acute renal failure, anaphylaxis, or severe skin reactions. Discontinue use and seek medical attention if severe side effects occur.

Drug interaction

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• ACE inhibitors/ARBs: reduced antihypertensive effect; potential worsening of renal function.
• Diuretics: reduced diuretic efficacy; risk of renal impairment.
• Corticosteroids: increased risk of GI ulceration or bleeding.
• Lithium: may increase lithium levels.
• Methotrexate: may increase methotrexate toxicity.
• SSRIs/SNRIs: increased risk of bleeding.

Missed dose

If taking on a regular schedule and a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the usual dosing schedule. Do not double the dose to catch up. For as-needed use, this guidance does not apply.

Overdose

Symptoms may include nausea, vomiting, epigastric pain, drowsiness, blurred vision, tinnitus, or, in severe cases, metabolic acidosis, coma, acute renal failure, and cardiovascular collapse. In case of suspected overdose, seek immediate medical attention or contact a poison control center. Do not induce vomiting unless instructed by a healthcare professional. Treatment is supportive and may include gastric lavage, activated charcoal, and correction of electrolyte imbalances.

Storage

Store at room temperature (20–25°C or 68–77°F) in a dry place, protected from light and moisture. Keep the bottle tightly closed. Do not store in the bathroom. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

(Note: Fictitious examples based on common feedback patterns)

• “As a rheumatologist, I have prescribed Motrin for years. Its anti-inflammatory effect is reliable, and most patients tolerate it well with proper dosing.” – Dr. Elena M., MD
• “Effective for my tension headaches without causing drowsiness. I always take it with food to avoid stomach upset.” – Michael T.
• “Used the children’s suspension for my son’s fever—worked quickly and he liked the taste. Followed weight-based dosing per pediatrician.” – Sarah L.
• “I rely on Motrin for post-workout muscle soreness. It reduces inflammation and lets me recover faster.” – James K.
• “Be cautious with long-term use; I experienced mild gastric discomfort after several months, but my doctor adjusted my regimen.” – Linda R.