Naprosyn: Effective Relief from Pain and Inflammation
Naprosyn
| Product dosage: 250mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 60 | 1.09 $ | 65.52 $ (0%) | 🛒 Add to cart |
| 90 | 0.97 $ | 98.28 $ 87.75 $ (11%) | 🛒 Add to cart |
| 120 | 0.93 $ | 131.04 $ 111.15 $ (15%) | 🛒 Add to cart |
| 180 | 0.87 $ | 196.56 $ 156.78 $ (20%) | 🛒 Add to cart |
| 270 | 0.84 $ | 294.84 $ 225.81 $ (23%) | 🛒 Add to cart |
| 360 | 0.82 $
Best per pill | 393.12 $ 296.01 $ (25%) | 🛒 Add to cart |
| Product dosage: 500mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 60 | 1.09 $ | 65.52 $ (0%) | 🛒 Add to cart |
| 90 | 1.00 $ | 98.28 $ 90.09 $ (8%) | 🛒 Add to cart |
| 120 | 0.96 $ | 131.04 $ 114.66 $ (12%) | 🛒 Add to cart |
| 180 | 0.89 $ | 196.56 $ 160.29 $ (18%) | 🛒 Add to cart |
| 270 | 0.87 $ | 294.84 $ 235.17 $ (20%) | 🛒 Add to cart |
| 360 | 0.84 $
Best per pill | 393.12 $ 304.20 $ (23%) | 🛒 Add to cart |
Synonyms | |||
Naprosyn is a trusted nonsteroidal anti-inflammatory drug (NSAID) containing naproxen as its active ingredient. It is widely prescribed for managing moderate pain, reducing inflammation, and alleviating fever. With a well-established efficacy and safety profile, Naprosyn offers targeted relief for a variety of acute and chronic conditions, making it a cornerstone in pain management protocols. Its extended duration of action allows for less frequent dosing, enhancing patient compliance and comfort.
Features
- Active ingredient: Naproxen (as naproxen sodium or naproxen base)
- Available in tablet, extended-release tablet, and oral suspension forms
- Dosage strengths: 250 mg, 375 mg, 500 mg tablets; 750 mg extended-release
- Prescription and over-the-counter (lower strength) formulations available
- Onset of action: approximately 1 hour for pain relief
- Duration: up to 12 hours per dose for standard formulations
- Half-life: 12–17 hours, permitting sustained therapeutic effect
Benefits
- Provides potent anti-inflammatory, analgesic, and antipyretic effects
- Reduces swelling, stiffness, and joint pain associated with arthritis
- Effective for acute pain conditions such as sprains, strains, and postoperative discomfort
- Long-lasting relief minimizes dosing frequency and supports daily activity
- Available in multiple formulations to suit individual patient needs and preferences
- Backed by extensive clinical research and decades of real-world use
Common use
Naprosyn is commonly prescribed for the management of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, juvenile arthritis, tendinitis, bursitis, and acute gout. It is also effective in treating primary dysmenorrhea and mild to moderate musculoskeletal pain, such as that caused by injuries or overexertion. In lower over-the-counter strengths, it is indicated for temporary relief of minor aches and pains, including headaches, toothaches, backaches, and menstrual cramps, as well as reduction of fever.
Dosage and direction
For rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis, the typical adult dosage is 250 mg to 500 mg twice daily. The maximum daily dose should not exceed 1,500 mg for limited periods, with a usual maintenance dose not exceeding 1,000 mg daily. For acute pain and primary dysmenorrhea, an initial dose of 500 mg may be followed by 250 mg every 6–8 hours as needed, not to exceed 1,250 mg on the first day and 1,000 mg on subsequent days. For over-the-counter use, adults and children 12 years and older may take 220 mg every 8–12 hours, not exceeding 660 mg in 24 hours. Tablets should be taken with a full glass of water, with food or milk to minimize gastrointestinal upset. Do not crush, chew, or break extended-release tablets.
Precautions
Use the lowest effective dose for the shortest duration possible. Patients with a history of gastrointestinal bleeding, ulceration, or perforation should use Naprosyn with extreme caution. Avoid use in patients with preexisting renal or hepatic impairment; periodic monitoring of renal and liver function is advised during long-term therapy. Caution is recommended in elderly patients, who may be more susceptible to adverse effects. Naprosyn may cause fluid retention and edema; use with care in patients with hypertension, cardiac failure, or other conditions predisposing to fluid retention. It may also impair fertility in women; this effect is reversible upon discontinuation.
Contraindications
Naprosyn is contraindicated in patients with known hypersensitivity to naproxen, aspirin, or other NSAIDs. Do not use in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Contraindicated in the setting of coronary artery bypass graft (CABG) surgery. Avoid use in patients with active gastrointestinal bleeding or peptic ulcer disease. Not recommended during the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus. Should not be used in patients with severe renal impairment or in those with severe hepatic failure.
Possible side effect
Common side effects include nausea, epigastric pain, heartburn, dizziness, drowsiness, headache, and mild fluid retention. Less frequently, it may cause constipation, diarrhea, flatulence, vomiting, stomatitis, tinnitus, visual disturbances, and skin rash. Serious side effects, though rare, include gastrointestinal bleeding, perforation, or ulceration; hepatotoxicity; renal papillary necrosis; acute renal failure; aseptic meningitis; Stevens-Johnson syndrome; toxic epidermal necrolysis; anaphylactoid reactions; and exacerbation of asthma. Cardiovascular risk such as myocardial infarction and stroke may increase with prolonged use.
Drug interaction
Naprosyn may increase the toxicity of lithium, methotrexate, cyclosporine, and phenytoin by reducing their renal clearance. Concurrent use with other NSAIDs or corticosteroids increases the risk of gastrointestinal adverse effects. It may reduce the antihypertensive effect of ACE inhibitors, angiotensin II receptor blockers, and beta-blockers. May potentiate the effects of warfarin and other anticoagulants, increasing the risk of bleeding. Diuretics may have reduced efficacy when used with Naprosyn. Concomitant use with selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) may elevate the risk of bleeding.
Missed dose
If a dose is missed, take it as soon as remembered, unless it is almost time for the next scheduled dose. In that case, skip the missed dose and resume the usual dosing schedule. Do not double the dose to make up for a missed one.
Overdose
Symptoms of overdose may include drowsiness, heartburn, indigestion, nausea, vomiting, epigastric pain, gastrointestinal bleeding, rare cases of metabolic acidosis, apnea, coma, convulsions, and renal failure. In case of suspected overdose, seek immediate medical attention. Management is supportive and may include gastric lavage, activated charcoal, and correction of electrolyte imbalances. Hemodialysis is not effective due to high protein binding.
Storage
Store at room temperature (20–25°C or 68–77°F), in a dry place, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or qualified healthcare provider before starting any new medication or changing your current regimen. Do not disregard professional medical advice or delay seeking it because of something you have read here.
Reviews
Clinical studies and patient reports consistently affirm Naprosyn’s effectiveness in reducing pain and inflammation, with many users noting significant improvement in mobility and quality of life. Some users report mild gastrointestinal discomfort, which often subsides with continued use or when taken with food. Long-term users appreciate the balance of efficacy and tolerability, though adherence to prescribed dosing and regular monitoring is emphasized. Overall, it remains a widely trusted option in its class.