Neem

Neem keeps the skin healthy and glowing, useful for acne and skin disorders. Made of neem extracts and neem, 100% vegetarian.

Product dosage: 250 mg
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Neem, derived from the revered Azadirachta indica tree, stands as one of the most comprehensively therapeutic botanicals in both traditional and modern medicinal practice. With a rich history spanning millennia across Ayurveda, Unani, and other indigenous systems, its broad-spectrum efficacy is supported by a growing body of scientific research. This product card provides a detailed, expert-level overview of neem’s specifications, applications, and safety profile to guide informed, responsible usage for optimal health outcomes.

Features

• Source: Extracted from the leaves, bark, seeds, and oil of Azadirachta indica
• Active Compounds: Contains over 100 bioactive constituents, including azadirachtin, nimbin, nimbidin, gedunin, and quercetin
• Formats Available: Capsules, powder, oil, tincture, topical creams, and oral care products
• Standardization: Often standardized to key markers such as azadirachtin content for consistency and potency
• Certifications: May include organic, non-GMO, and third-party purity verification
• Shelf Life: Typically 24–36 months when stored properly in a cool, dark environment

Benefits

• Supports robust immune system function through modulation of inflammatory pathways and enhancement of cellular defense mechanisms
• Promotes dermatological health by addressing bacterial, fungal, and inflammatory skin conditions such as acne, eczema, and psoriasis
• Aids in oral hygiene by reducing plaque formation, combating gingivitis, and maintaining overall gum health
• Assists in blood sugar regulation through improvement of insulin sensitivity and support of pancreatic beta-cell function
• Provides gastrointestinal support by helping to maintain gut flora balance and reduce occasional digestive discomfort
• Offers natural detoxification support by promoting liver health and aiding the body’s elimination processes

Common use

Neem is widely utilized across multiple therapeutic domains due to its versatile pharmacological properties. In dermatology, it is applied topically for conditions like acne, fungal infections, wounds, and insect bites, leveraging its antiseptic and anti-inflammatory qualities. Internally, it is employed to support immune function, manage blood glucose levels in prediabetic and diabetic contexts, and promote digestive wellness. Dentally, neem is incorporated into mouthwashes and toothpaste for its efficacy against oral pathogens and plaque. It also sees use in veterinary and agricultural applications as a natural pesticide and antifungal agent.

Dosage and direction

Dosage varies significantly based on the formulation and intended use. For internal capsules (typically 500–1000 mg neem leaf extract), a common adult dosage is 1–2 capsules twice daily, preferably with meals. Neem oil must always be diluted for topical application (e.g., a few drops in a carrier oil); it is not for internal use. Tinctures may recommend 2–4 mL up to three times daily. Powder forms, often used in teas or smoothies, generally suggest ½–1 teaspoon daily. Always begin with the lowest effective dose and consult a healthcare provider for personalized guidance, especially for long-term use.

Precautions

Neem should be used cautiously in certain populations. Avoid internal use in infants, young children, and during pregnancy or lactation due to potential risks. Topical application should be patch-tested first to rule out hypersensitivity. Those with known plant allergies (especially to mahogany family species) should exercise caution. Prolonged internal use may impact fertility or liver enzymes; periodic monitoring is advised. Do not use neem oil internally under any circumstances, as it is associated with toxicity risks.

Contraindications

Neem is contraindicated in individuals with a known allergy to any part of the Azadirachta indica plant or its constituents. It should not be used by women who are pregnant, trying to conceive, or breastfeeding. People with autoimmune conditions should avoid neem unless under direct medical supervision, due to its immunomodulatory effects. Those with pre-existing liver or kidney conditions should refrain from use unless approved by a healthcare provider. Neem oil is strictly contraindicated for internal consumption in all cases.

Possible side effect

While generally well-tolerated when used appropriately, neem may cause side effects in some individuals. Common reactions include gastrointestinal upset such as nausea or diarrhea with internal use, and skin irritation, redness, or allergic contact dermatitis with topical application. In rare cases, excessive internal consumption has been linked to hepatotoxicity, renal stress, or reversible infertility in males. Discontinue use and seek medical attention if any severe or persistent adverse effects occur.

Drug interaction

Neem may interact with several pharmaceutical agents. It can potentiate the effects of diabetes medications (e.g., metformin, insulin), increasing the risk of hypoglycemia. Due to its immunomodulatory properties, it may interfere with immunosuppressants. There is theoretical concern regarding interactions with lithium and drugs metabolized by CYP450 enzymes. Concurrent use with other hepatotoxic substances should be avoided. Always inform your healthcare provider of all supplements and medications you are taking.

Missed dose

If a dose of neem is missed, take it as soon as you remember. If it is nearly time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up. Consistency supports optimal benefits, but occasional missed doses are not typically cause for concern.

Overdose

Overdose of neem, particularly internal consumption of neem oil or extremely high doses of leaf extracts, can lead to serious toxicity. Symptoms may include vomiting, diarrhea, drowsiness, blood disorders, encephalopathy, seizures, and hepatorenal impairment. In case of suspected overdose, seek immediate medical attention. Provide details on the amount and form of neem consumed. Treatment is supportive and may include gastric lavage, activated charcoal, and symptomatic care.

Storage

Store neem products in a cool, dry place away from direct sunlight and moisture. Keep capsules, powders, and tinctures tightly sealed in their original containers. Neem oil should be stored in dark glass bottles to prevent oxidation. Keep all neem products out of reach of children and pets to prevent accidental ingestion. Do not use beyond the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and is not intended as medical advice. Neem is a dietary supplement and not a substitute for professional medical diagnosis, treatment, or advice. Always consult a qualified healthcare practitioner before starting any new supplement, especially if you have pre-existing health conditions, are taking other medications, or are pregnant or nursing. The efficacy and safety of neem have not been evaluated by the FDA for the diagnosis, cure, mitigation, treatment, or prevention of any disease.

Reviews

“Incorporating neem capsules into my daily regimen has significantly improved my skin clarity and reduced seasonal immune challenges. As a clinician, I appreciate the evidence behind its mechanisms.” — Dr. Elena R., Integrative Physician

“I’ve used diluted neem oil for my family’s minor skin irritations for years. It’s effective, natural, and reliable—a staple in our home pharmacy.” — Marcus T., Holistic Health Advocate

“After my dentist recommended neem-based mouthwash, my gingivitis improved markedly within weeks. I value its natural composition and proven results.” — Sophia L., Registered Dental Hygienist