Nurofen

Nurofen is a well-established over-the-counter (OTC) analgesic and anti-inflammatory medication, with ibuprofen as its active pharmaceutical ingredient. It belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs) and is widely utilized for its efficacy in managing mild to moderate pain, reducing fever, and alleviating inflammation. Its mechanism of action involves the inhibition of cyclooxygenase (COX) enzymes, thereby reducing the production of prostaglandins, which are mediators of pain, fever, and inflammatory responses. Available in various formulations including tablets, capsules, and liquid suspensions, Nurofen offers flexibility in administration tailored to patient needs and preferences.

Features

• Active ingredient: Ibuprofen (typically 200mg per standard tablet, other strengths available)
• Pharmaceutical class: Nonsteroidal anti-inflammatory drug (NSAID)
• Formulations: Coated tablets, liquid capsules, oral suspension, and effervescent tablets
• Rapid absorption and onset of action, with peak plasma concentrations reached within 1-2 hours post-administration
• Demonstrated anti-inflammatory, analgesic, and antipyretic properties
• Multiple product lines tailored for specific needs (e.g., Nurofen Express, Nurofen Migraine Pain)

Benefits

• Provides effective and rapid relief from various types of pain, including headache, dental pain, menstrual cramps, and musculoskeletal discomfort
• Reduces inflammation and associated symptoms such as swelling and stiffness in conditions like arthritis
• Lowers elevated body temperature effectively in febrile states
• Enables improved daily functioning and quality of life by alleviating discomfort
• Available in multiple formulations to suit different age groups and patient preferences
• Supported by extensive clinical evidence and decades of safe use under appropriate guidance

Common use

Nurofen is commonly used for the symptomatic relief of mild to moderate pain, including but not limited to headaches, migraines, dental pain, dysmenorrhea, and musculoskeletal pain such as that associated with back strain or osteoarthritis. It is also indicated for the reduction of fever in adults and children. Its anti-inflammatory properties make it suitable for conditions where inflammation is a contributing factor to pain.

Dosage and direction

For adults and children over 12 years, the usual dose is one 200mg tablet up to three times a day as needed, with doses spaced at least 4 hours apart. Do not exceed 1200mg in any 24-hour period. For other formulations such as liquid suspensions, follow weight-based or age-based dosing instructions provided on the packaging or as directed by a healthcare professional. Take with food or milk to minimize gastrointestinal upset. Swallow tablets whole with water; do not crush or chew.

Precautions

• Use the lowest effective dose for the shortest duration necessary to control symptoms.
• Avoid use in patients with a history of gastrointestinal ulcers or bleeding.
• Exercise caution in patients with cardiovascular risk factors, renal impairment, or dehydration.
• Not recommended during the third trimester of pregnancy; consult a healthcare provider before use in earlier trimesters.
• Discontinue use and seek medical advice if allergic reactions or signs of gastrointestinal bleeding occur.

Contraindications

• Hypersensitivity to ibuprofen, other NSAIDs, or any excipients in the formulation.
• History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
• Active peptic ulcer disease or history of recurrent ulceration/bleeding.
• Severe heart failure, hepatic failure, or renal failure.
• Third trimester of pregnancy.
• Concurrent use of other NSAIDs, including COX-2 inhibitors.

Possible side effect

Common side effects may include gastrointestinal discomfort, nausea, dyspepsia, and dizziness. Less frequently, rash, tinnitus, edema, and elevated blood pressure may occur. Rare but serious side effects include gastrointestinal bleeding, cardiovascular events such as myocardial infarction or stroke, severe skin reactions, and hepatotoxicity. Patients should discontinue use and consult a healthcare provider if severe or persistent adverse effects are experienced.

Drug interaction

Ibuprofen may interact with several medication classes:

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• Other NSAIDs or corticosteroids: increased risk of gastrointestinal adverse effects.
• ACE inhibitors, angiotensin II receptor blockers, and diuretics: reduced antihypertensive efficacy and potential worsening of renal function.
• Methotrexate: increased methotrexate toxicity.
• Aspirin (at cardioprotective doses): may diminish aspirin’s antiplatelet effect.

Consult a healthcare provider or pharmacist before combining Nurofen with other medications.

Missed dose

As Nurofen is taken on an as-needed basis for symptomatic relief, there is no fixed dosing schedule. If a dose is missed and symptoms persist, take it as soon as remembered, provided the next dose is not due soon. Do not double the dose to make up for a missed one.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric pain, drowsiness, and blurred vision. In severe cases, metabolic acidosis, renal failure, seizures, or coma may occur. Seek immediate medical attention if overdose is suspected. Treatment is supportive and may include gastric lavage, activated charcoal, and monitoring of vital organ function.

Storage

Store at room temperature (15-25°C), in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes and does not replace professional medical advice. Always read the label and patient information leaflet before use. Consult a healthcare provider for diagnosis and appropriate treatment recommendations, especially if symptoms persist or worsen.

Reviews

Nurofen is consistently rated highly by consumers for its effectiveness in providing rapid relief from pain and fever. Users frequently note its reliability for headaches, period pain, and muscular aches. Healthcare professionals regard it as a well-tolerated option when used appropriately, emphasizing the importance of adhering to recommended dosages and precautions.