Periactin

Periactin is used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, and other symptoms of allergies and the common cold.

Product dosage: 4mg
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Synonyms Apetamin-p Apeton Apitup Arictin Axoprol Cipla-actin Ciplactin Cipractin Cipractine Ciproeptadina Ciproheptadina Ciprolisina Ciprovit Ciptadine Complamin Covitasa b12 Cuplactin Cyproatin Cyprodin Cyprogin Cyproheptadin Cyproheptadinum Cypromin Cyprotol Dronactin Dynamogen Ennamax Esprocy Glocyp Glutodina Heptagyl Heptasan Ifrasal Kulinet Lexahist Lupactin Nuran Oractine Pangavit Periactine Periactinol Poncohist Practin Prakten Prohessen Pronicy Sipraktin Triactin Trimetabol Viternum

Periactin (cyproheptadine hydrochloride) is a first-generation antihistamine and serotonin antagonist with significant appetite-stimulating properties. Primarily indicated for allergic conditions, its off-label use for appetite enhancement has been well-documented in clinical practice. This medication works through multiple mechanisms to address poor nutritional intake, making it particularly valuable in cases of unintentional weight loss and cachexia. Under proper medical supervision, Periactin offers a pharmacological approach to support nutritional rehabilitation in appropriate patient populations.

Features

• Contains cyproheptadine hydrochloride as active ingredient
• Available in 4mg scored tablets and syrup formulation (2mg/5mL)
• Dual mechanism: histamine H1-receptor antagonist and serotonin antagonist
• Rapid onset of action with effects typically noticeable within 1-2 hours
• Long duration of effect (4-6 hours per dose)
• Well-established safety profile with decades of clinical use
• Multiple therapeutic applications beyond appetite stimulation

Benefits

• Promotes significant appetite increase in underweight patients
• Supports weight gain in cases of malnutrition and cachexia
• Helps manage allergic conditions concurrently with appetite issues
• Provides predictable dosing with flexible administration options
• Offers cost-effective therapeutic intervention
• May improve overall quality of life through better nutritional status

Common use

Periactin is FDA-approved for the treatment of allergic conditions including seasonal allergies, perennial allergic rhinitis, and chronic urticaria. Its off-label use for appetite stimulation represents a significant portion of clinical applications, particularly in pediatric populations experiencing failure to thrive, elderly patients with age-related anorexia, and individuals with cancer-related cachexia. The medication has also shown utility in managing serotonin syndrome and migraine prophylaxis in certain cases.

Dosage and direction

For appetite stimulation in adults: Initial dose of 4mg three times daily, titrated upward based on response and tolerance. Maximum daily dose should not exceed 32mg. For pediatric patients (2-14 years): 0.25mg/kg/day or 8mg/m²/day divided into three or four doses, not to exceed 16mg daily. Administration with food may minimize potential gastrointestinal discomfort. Regular monitoring of weight and nutritional status is recommended during therapy.

Precautions

Patients should avoid alcohol and CNS depressants while taking Periaptin due to additive sedative effects. Use with caution in patients with hypertension, cardiovascular disease, hyperthyroidism, or prostatic hypertrophy. Elderly patients may experience increased sensitivity to anticholinergic effects. Regular ophthalmologic examinations are recommended during prolonged therapy due to potential for increased intraocular pressure.

Contraindications

Periactin is contraindicated in patients with known hypersensitivity to cyproheptadine or other antihistamines of similar chemical structure. Additional contraindications include narrow-angle glaucoma, urinary retention, peptic ulcer disease, and concurrent MAOI therapy. Should not be used in neonates or premature infants due to increased risk of anticholinergic effects.

Possible side effect

Common side effects include drowsiness (14-25%), dizziness (6-12%), dry mouth (15-30%), and increased appetite (20-40%). Less frequent effects include blurred vision, constipation, weight gain, and photosensitivity. Serious but rare adverse reactions include seizures, hallucinations, and hematologic abnormalities. Most side effects are dose-dependent and often diminish with continued therapy.

Drug interaction

Periactin may potentiate effects of CNS depressants including alcohol, barbiturates, and opioids. Concurrent use with MAOIs may prolong and intensify anticholinergic effects. May diminish the effects of oral anticoagulants. Serotonergic drugs may interact through competitive receptor binding. Always inform healthcare providers of all medications being taken.

Missed dose

If a dose is missed, take it as soon as remembered unless it is nearly time for the next scheduled dose. Do not double doses to make up for missed administration. Maintain regular dosing schedule to ensure consistent therapeutic effect. Consult healthcare provider if multiple doses are missed.

Overdose

Symptoms of overdose may include extreme drowsiness, confusion, hallucinations, seizures, and cardiovascular collapse. In children, paradoxical CNS stimulation may occur. Treatment is supportive and symptomatic. Gastric lavage may be indicated if ingestion was recent. Physostigmine may be used for severe anticholinergic effects under medical supervision.

Storage

Store at controlled room temperature (20-25°C/68-77°F). Protect from light and moisture. Keep in original container with tight closure. Keep out of reach of children and pets. Do not use after expiration date printed on packaging. Properly dispose of unused medication according to local regulations.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Periactin is a prescription medication that should only be used under direct medical supervision. Individual results may vary. Always consult with a qualified healthcare professional before starting or changing any medication regimen. Not all uses described may be approved in your region.

Reviews

Clinical studies demonstrate Periactin’s efficacy in appetite stimulation, with weight gain observed in 60-80% of treated patients within 4-8 weeks. Patient satisfaction surveys indicate improved quality of life measures related to nutritional status. Medical professionals appreciate its predictable response profile and established safety record. Ongoing research continues to explore optimal dosing strategies and additional therapeutic applications.