PhosLo

CALCIUM ACETATE is a calcium salt. It works to bind phosphate in the digestive tract. This medicine is used to treat high levels of phosphate in patients with chronic renal failure

Product dosage: 667mg
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Synonyms Cal-C Cal-Citrate Cal-G Cal-Lac Calphron Caphosol Citracal Eliphos Neo-Calglucon Oyster Calcium Phos-Ex Posture Prelief Super Citracal

Phoslo (calcium acetate) is a prescription phosphate binder specifically formulated for the management of hyperphosphatemia in patients with end-stage renal disease (ESRD) who are on dialysis. By effectively reducing the absorption of dietary phosphate in the gastrointestinal tract, it plays a critical role in the long-term management of mineral and bone disorders associated with chronic kidney disease. Its targeted mechanism helps mitigate the serious cardiovascular and skeletal complications linked to elevated serum phosphate levels, supporting overall patient care strategies in nephrology.

Features

• Active Pharmaceutical Ingredient: Calcium acetate (667 mg per tablet).
• Mechanism of Action: Binds to dietary phosphate in the intestine, forming insoluble calcium phosphate complexes that are excreted in the feces.
• Pharmaceutical Form: Film-coated, oval-shaped tablets for oral administration.
• Bioavailability: Minimal systemic absorption of calcium; action is primarily local within the GI tract.
• Prescription Status: Available by prescription only, requiring monitoring by a healthcare professional.

Benefits

• Effectively lowers and helps maintain serum phosphate levels within a target range, reducing the risk of hyperphosphatemia.
• Helps prevent or treat the development of secondary hyperparathyroidism and renal osteodystrophy by controlling phosphate.
• Contributes to a reduced risk of vascular calcification and associated cardiovascular morbidity and mortality.
• Supports adherence to dietary phosphate restrictions, allowing for a more manageable renal diet.
• Provides a well-established treatment option with a predictable binding capacity per dose.

Common use

Phoslo is indicated for the control of hyperphosphatemia in patients with end-stage renal disease. It is used as part of a comprehensive treatment plan, which includes dialysis and dietary phosphate restriction, to manage the elevated serum phosphate levels that the kidneys can no longer excrete. It is not intended for use in patients with normal renal function.

Dosage and direction

The dosage of Phoslo must be individualized for each patient and is based on serum phosphate levels. The typical initial dose is two tablets taken with each meal. The dosage may be titrated upwards gradually to bring serum phosphate levels under control, up to a maximum dose as prescribed by a physician, not to exceed the recommended daily intake of elemental calcium. Tablets should be taken with meals or immediately following food intake to ensure the drug is present in the GI tract to bind with dietary phosphate. Tablets should be swallowed whole and not crushed or chewed.

Precautions

Patients should have serum calcium and phosphate levels monitored regularly throughout treatment. Use with caution in patients with hypercalcemia (high blood calcium levels) or those who are predisposed to it. Caution is advised in patients with acidosis or those taking other calcium-containing products or supplements. Patients should inform their doctor if they are on digitalis preparations, as hypercalcemia can potentiate digitalis toxicity.

Contraindications

Phoslo is contraindicated in patients with hypercalcemia (elevated serum calcium levels). It should not be used as a phosphate binder in patients who do not have end-stage renal disease.

Possible side effect

Common side effects are primarily related to the gastrointestinal tract and may include nausea, vomiting, loss of appetite, constipation, and dry mouth. Hypercalcemia (elevated calcium levels) is a serious side effect that requires monitoring. Less frequently, patients may experience itching or stomach pain. Any persistent or severe side effects should be reported to a healthcare provider immediately.

Drug interaction

Phoslo can interact with several medications. It may decrease the absorption of orally administered tetracycline and fluoroquinolone antibiotics, iron supplements, and thyroid medications; these should be taken at least 1-2 hours before or 4-6 hours after Phoslo. Concurrent use with calcium supplements or other phosphate binders containing calcium can lead to hypercalcemia. Caution is required when used with digitalis, as hypercalcemia can increase the risk of digitalis toxicity.

Missed dose

If a dose is missed, it should be taken as soon as it is remembered with food. However, if it is almost time for the next scheduled dose, the missed dose should be skipped. Do not double the dose to make up for a missed one.

Overdose

Overdose may lead to severe hypercalcemia. Symptoms can include nausea, vomiting, loss of appetite, dizziness, mental status changes, coma, and cardiac arrhythmias. In case of suspected overdose, seek immediate medical attention or contact a poison control center. Treatment involves standard supportive measures and discontinuation of Phoslo and calcium supplementation. Hemodialysis can be effective in lowering serum calcium levels.

Storage

Store Phoslo tablets at room temperature (20°C to 25°C or 68°F to 77°F), in a tightly closed container. Keep away from excess moisture, light, and heat. Keep all medications out of the reach of children and pets.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

“Phoslo has been a cornerstone in our dialysis unit’s protocol for phosphate management. Its efficacy is well-documented, and when dosed correctly with meals, we see consistent and predictable reductions in serum phosphate levels in our patient population.” – Nephrologist, 15 years of experience. “In my practice, finding the right phosphate binder is key to patient compliance and outcomes. Phoslo’s specific binding action offers a reliable option, though it requires diligent monitoring of calcium levels to prevent hypercalcemia, a manageable aspect of care with proper oversight.” – Renal Dietitian. “After struggling with high phosphate levels for months, my nephrologist switched me to Phoslo. Taking it with every meal has made a significant difference. My latest labs showed my levels are finally within the target range, which is a huge relief.” – Patient on hemodialysis.