Provera

Provera improves women’s condition when menstrual periods have stopped or in case of an abnormal bleeding of uterus due to hormone imbalance.

Product dosage: 10mg
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Synonyms Amen Apo-medroxy Aragest Ciclotal Climanor Contracep Curretab Cycrin Depo-clinovir Depo-prodasone Depo-progevera Depo-provera Depocon Depotrust Deviry Dugen Duova Enaf Farlutal Farlutale Femihexal Gestapuran Gestomikron Hexal-mpa Hysron Livomedrox LunelleLutoral Lyndavel Medkiron Medroplex Medrosterona Medroxiprogesterona Medroxyhexal Medroxyprogesteron Medroxyprogesteronacetat Medroxyprogesteronum Megestron Mepastat Meprate Mepro Methypregnone Metigesterona Modus Mpa-beta Nerfin Non-preg Novo-medrone Perlutex Petogen Petogen-fresenius Planibu Prodafem Prodasone Progeron Progestagen Progevera Ralovera Roxyprog Sayana Veraplex

Provera is a prescription medication containing medroxyprogesterone acetate, a synthetic form of the natural hormone progesterone. It is primarily indicated for the treatment of secondary amenorrhea and abnormal uterine bleeding due to hormonal imbalance. This progestin therapy helps restore hormonal equilibrium, supports endometrial health, and provides predictable menstrual cycle regulation under medical supervision. Proper diagnosis and ongoing monitoring by a healthcare provider are essential for safe and effective use.

Features

• Contains medroxyprogesterone acetate as the active ingredient
• Available in multiple tablet strengths (2.5 mg, 5 mg, 10 mg)
• Synthetic progestin with predictable pharmacokinetic profile
• Oral administration with once-daily dosing convenience
• Manufactured under strict pharmaceutical quality standards

Benefits

• Effectively restores menstrual regularity in women with secondary amenorrhea
• Reduces or eliminates abnormal uterine bleeding caused by hormonal imbalance
• Provides predictable cycle control when prescribed appropriately
• Helps prevent endometrial hyperplasia in estrogen-treated postmenopausal women
• Supports management of certain gynecological conditions under medical guidance
• May offer symptomatic relief in endometriosis-related discomfort (off-label use)

Common use

Provera is commonly prescribed for the treatment of secondary amenorrhea (absence of menstrual periods in women who have previously had periods) and abnormal uterine bleeding due to hormonal imbalance without organic pathology. It is also used in combination with estrogen for hormone replacement therapy in postmenopausal women to protect the uterine lining. Some healthcare providers may prescribe it off-label for endometriosis management or other progesterone-deficient conditions.

Dosage and direction

Dosage varies based on indication and individual patient factors. For secondary amenorrhea: 5-10 mg daily for 5-10 days, with withdrawal bleeding expected within 3-7 days after completion. For abnormal uterine bleeding: 5-10 mg daily for 5-10 days beginning on day 16 of cycle, with bleeding expected within 3-7 days after completion. For endometrial protection in estrogen-treated postmenopausal women: typically 2.5-10 mg daily for 12-14 consecutive days per month. Always take exactly as prescribed, with or without food as directed. Do not adjust dosage without medical consultation.

Precautions

Regular medical supervision is essential during treatment. Patients should undergo baseline and periodic physical examinations including blood pressure monitoring, breast examination, and pelvic examination. Use with caution in patients with history of depression, asthma, diabetes, migraine, seizure disorders, or cardiac/renal dysfunction. May cause fluid retention; use cautiously in patients with conditions that might be aggravated by fluid retention. Patients should be monitored for signs of thrombotic disorders. Discontinue immediately if sudden partial or complete vision loss, diplopia, or retinal vascular lesions occur.

Contraindications

Provera is contraindicated in patients with known hypersensitivity to medroxyprogesterone acetate or any component of the formulation. Additional contraindications include known or suspected pregnancy, undiagnosed abnormal genital bleeding, known or suspected breast malignancy, active thrombophlebitis or current or past history of thromboembolic disorders, cerebral vascular disease, liver dysfunction or disease, and missed abortion. Not for use as a contraceptive.

Possible side effect

Common side effects may include nausea, bloating, breast tenderness, headache, weight changes, dizziness, and fatigue. Less frequently reported effects include mood changes, insomnia, acne, hirsutism, alopecia, and changes in libido. Serious but rare side effects include thrombophlebitis, pulmonary embolism, retinal thrombosis, and optic neuritis. Any unusual side effects should be reported to a healthcare provider promptly.

Drug interaction

Provera may interact with aminoglutethimide, potentially decreasing progestin effects. Barbiturates, carbamazepine, phenytoin, rifampin, and St. John’s wort may increase metabolism of medroxyprogesterone acetate, potentially reducing efficacy. May affect glucose tolerance; diabetic patients should monitor blood glucose levels closely. Laboratory test interactions may occur with certain endocrine and liver function tests.

Missed dose

If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for a missed one. If multiple doses are missed or vomiting occurs shortly after administration, contact your healthcare provider for guidance. Maintain regular dosing schedule as prescribed.

Overdose

Acute overdose with Provera is unlikely to cause serious symptoms. However, large doses might cause nausea, vomiting, drowsiness, or dizziness. There is no specific antidote; treatment should be symptomatic and supportive. In case of suspected overdose, contact poison control center or seek immediate medical attention.

Storage

Store at room temperature (20-25°C/68-77°F) in the original container, protected from light and moisture. Keep tightly closed and out of reach of children. Do not use after expiration date printed on packaging. Properly discard any unused medication according to pharmaceutical disposal guidelines.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Provera is available by prescription only and should be used under appropriate medical supervision. Individual results may vary. Always consult with a qualified healthcare professional before starting, changing, or stopping any medication. The full prescribing information should be reviewed before use.

Reviews

Clinical studies demonstrate Provera’s efficacy in managing secondary amenorrhea with approximately 80% of patients experiencing withdrawal bleeding following treatment. In abnormal uterine bleeding studies, majority of patients showed significant improvement in bleeding patterns. Patient reviews generally report satisfactory results when used as directed under medical supervision, though individual experiences with side effects vary. Many users appreciate the predictable cycle regulation, while some report managing side effects through dosage adjustments under medical guidance.