Provigil: Enhance Wakefulness and Cognitive Performance
Provigil
| Product dosage: 100mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
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| 360 | 0.91 $
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| Product dosage: 200mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
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| 360 | 0.98 $
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Synonyms | |||
Provigil (modafinil) is a prescription medication indicated to improve wakefulness in adults with excessive sleepiness associated with narcolepsy, obstructive sleep apnea (OSA), or shift work sleep disorder. It promotes alertness without the typical stimulant side effects, making it a valuable option for managing sleep-related conditions. This product card provides a comprehensive overview for healthcare professionals and informed patients.
Features
- Active ingredient: Modafinil
- Available in 100 mg and 200 mg tablet strengths
- Schedule IV controlled substance
- Mechanism: Exact mechanism unknown; thought to work by increasing dopamine in the brain by inhibiting dopamine reuptake
- Half-life: Approximately 15 hours
- Onset of action: Within 1–2 hours
- Bioavailability: Not affected by food
Benefits
- Promotes sustained wakefulness and alertness during waking hours
- Reduces excessive daytime sleepiness in narcolepsy and OSA patients
- Helps shift workers maintain alertness during night shifts
- May improve cognitive function, including memory and focus, in certain off-label uses
- Generally well-tolerated with a lower risk of abuse compared to traditional stimulants
- Once-daily dosing supports adherence and convenience
Common use
Provigil is FDA-approved for the treatment of excessive sleepiness associated with narcolepsy, obstructive sleep apnea (with continued primary treatment such as CPAP), and shift work sleep disorder. Off-label, it is sometimes used for attention deficit hyperactivity disorder (ADHD), fatigue associated with multiple sclerosis, and depression, though these uses lack full FDA approval and require careful clinical consideration.
Dosage and direction
The recommended dose for narcolepsy or OSA is 200 mg taken orally once daily in the morning. For shift work sleep disorder, take 200 mg approximately one hour before the start of the work shift. Doses may be adjusted based on efficacy and tolerability, not to exceed 400 mg daily. Tablets should be swallowed whole with water; they may be taken with or without food.
Precautions
Use with caution in patients with a history of psychosis, depression, mania, or cardiovascular disease. Monitor for signs of misuse, dependency, or abuse, as Provigil is a controlled substance. It may interfere with hormonal contraceptives; advise alternative non-hormonal birth control methods. Regular monitoring of blood pressure and heart rate is recommended during treatment.
Contraindications
Provigil is contraindicated in patients with known hypersensitivity to modafinil or armodafinil. It should not be used in those with a history of left ventricular hypertrophy or ischemic ECG changes, chest pain, arrhythmias, or other significant cardiac conditions without careful evaluation.
Possible side effect
Common side effects may include headache, nausea, nervousness, anxiety, insomnia, dizziness, and diarrhea. Less frequently, dry mouth, decreased appetite, sweating, and palpitations may occur. Serious but rare side effects include Stevens-Johnson syndrome, angioedema, multiorgan hypersensitivity reactions, and psychiatric symptoms such as hallucinations or suicidal ideation.
Drug interaction
Provigil is a moderate inducer of CYP3A4/5 and inhibitor of CYP2C19. It may reduce the efficacy of drugs metabolized by CYP3A4, such as cyclosporine, midazolam, and hormonal contraceptives. Conversely, drugs that induce CYP3A4 (e.g., carbamazepine, rifampin) may decrease modafinil levels. Use caution with monoamine oxidase inhibitors (MAOIs), other CNS stimulants, or warfarin (monitor INR).
Missed dose
If a dose is missed, take it as soon as remembered unless it is close to the time for the next dose. Do not double the dose to make up for a missed one. For shift work sleep disorder, if missed before the shift, take as soon as possible unless the shift is nearly over.
Overdose
Overdose may result in symptoms such as insomnia, agitation, confusion, nausea, tachycardia, hypertension, or hallucinations. There is no specific antidote; treatment is symptomatic and supportive. Ensure adequate hydration and monitor vital signs. Contact a poison control center or seek emergency medical attention immediately.
Storage
Store at room temperature (20–25°C or 68–77°F) in a tightly closed container, away from light, moisture, and heat. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider for personalized recommendations. Do not start, stop, or change any medication without medical supervision.
Reviews
Clinical studies and patient reports generally indicate that Provigil is effective in promoting wakefulness and reducing daytime sleepiness, with many users noting improved quality of life. Some report mild side effects like headaches, which often subside with continued use. It is regarded as a useful option within its approved indications when used under medical guidance.