Secnidazole: Advanced Single-Dose Treatment for Parasitic and Bacterial Infections
Secnidazole
| Product dosage: 1 gr | |||
|---|---|---|---|
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| 60 | 1.85 $ | 193.05 $ 111.15 $ (42%) | 🛒 Add to cart |
| 120 | 1.30 $
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Synonyms | |||
Secnidazole is a next-generation nitroimidazole antimicrobial agent designed to target anaerobic bacteria and protozoa with high efficacy and a favorable pharmacokinetic profile. It is particularly valued for its extended half-life, which allows for single-dose or short-course regimens, enhancing patient adherence and reducing the risk of resistance development. This makes it a cornerstone in the management of conditions such as bacterial vaginosis, amoebiasis, and giardiasis, offering both clinical reliability and patient convenience.
Features
- Belongs to the nitroimidazole class of antimicrobials
- Extended half-life of approximately 17–29 hours
- Effective against anaerobic bacteria and protozoa
- Available in oral granular formulations for single-dose administration
- High tissue penetration and bioavailability
Benefits
- Enables single-dose or short-course treatment, improving compliance
- Rapid symptomatic relief and high cure rates for targeted infections
- Reduced risk of antimicrobial resistance due to shorter treatment duration
- Convenient administration, often without the need for multiple daily doses
- Well-tolerated profile with a low incidence of severe adverse effects
Common use
Secnidazole is primarily indicated for the treatment of bacterial vaginosis in adult women. It is also used for intestinal amoebiasis (both luminal and invasive forms), amoebic liver abscess, and giardiasis. Its broad-spectrum activity against anaerobic pathogens makes it suitable for a range of infections where these microorganisms are implicated.
Dosage and direction
For bacterial vaginosis: a single 2 g oral dose. For intestinal amoebiasis: a single 2 g dose daily for 3 days in adults, or 30 mg/kg (max 2 g) daily for 3 days in children. For giardiasis: a single 2 g dose in adults, or 30 mg/kg (max 2 g) in children. Administer with food to minimize gastrointestinal upset. The granules should be sprinkled on applesauce, yogurt, or pudding and consumed immediately without chewing.
Precautions
Use with caution in patients with central or peripheral nervous system disorders, as nitroimidazoles may exacerbate neurological symptoms. Avoid in patients with blood dyscrasias or a history thereof. Alcohol consumption should be avoided during and for at least 72 hours after treatment due to the risk of a disulfiram-like reaction. Use in pregnancy only if clearly needed; weigh benefits against potential risks.
Contraindications
Hypersensitivity to secnidazole, other nitroimidazoles, or any component of the formulation. Contraindicated in the first trimester of pregnancy. Not recommended for patients with severe hepatic impairment.
Possible side effect
Common side effects include nausea, vomiting, diarrhea, abdominal pain, headache, and metallic taste. Less frequently, dizziness, fatigue, and allergic reactions such as rash may occur. Rare but serious effects include peripheral neuropathy, seizures, and leukopenia.
Drug interaction
Secnidazole may potentiate the effects of warfarin and other oral anticoagulants, requiring close monitoring of prothrombin time. Concurrent use with disulfiram or alcohol-containing products should be avoided. It may also interact with drugs that induce or inhibit CYP450 enzymes, though data are limited.
Missed dose
Since secnidazole is often administered as a single dose, missed dose scenarios are uncommon. If a multi-day regimen is prescribed and a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose.
Overdose
Symptoms of overdose may include nausea, vomiting, ataxia, and neurological disturbances. There is no specific antidote; treatment is supportive and symptomatic. Gastric lavage may be considered if ingestion was recent.
Storage
Store at room temperature (15–30°C), in a dry place, protected from light. Keep out of reach of children and pets. Do not use after the expiration date.
Disclaimer
This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment decisions, and personalized recommendations. Dosage and indications may vary based on regional guidelines and individual patient factors.
Reviews
Clinical studies and post-marketing surveillance indicate high patient satisfaction with secnidazole, particularly due to the convenience of single-dose therapy. Efficacy rates for bacterial vaginosis exceed 80% in most trials, with similar success in parasitic infections. Tolerability is generally good, though gastrointestinal side effects are noted in a minority of users.