Unisom

Unisom as a single drug (not part of a combination) used as a short-term treatment for sleep problems (insomnia).

Product dosage: 25mg
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Synonyms Decapryn Donormyl Dormidina Dossilamina Doxilamina Doxilamine Doxilmina Doxilminio Doxinate Doxylamin Doxylaminum Dozile Gittalun Histadoxylamine Hoggar Lidene Mereprine Nocpaz Restavit Restwel Sanalepsin Sedaplus Somnia Sulamine Valocordin Vistaril12 Zarcop Zyrtec4

Unisom SleepTabs, containing the active ingredient doxylamine succinate, is an over-the-counter sleep aid designed for the short-term treatment of occasional insomnia. As an antihistamine with sedative properties, it works by blocking histamine receptors in the brain, promoting drowsiness and helping you fall asleep faster. This non-habit forming solution is a trusted choice for those seeking relief from sleeplessness without a prescription, providing a restful night’s sleep so you can wake up refreshed and ready for the day.

Features

• Active ingredient: Doxylamine succinate 25 mg per tablet
• Form: Easy-to-swallow, film-coated tablets
• Indication: For the relief of occasional sleeplessness
• Onset of action: Typically within 30 minutes
• Duration: Provides up to 6-8 hours of sleep
• Non-habit forming when used as directed
• Gluten-free formulation
• Available without a prescription

Benefits

• Reduces time to fall asleep, helping you achieve sleep onset more quickly.
• Improves sleep maintenance, decreasing nighttime awakenings.
• Enhances overall sleep quality for next-day alertness and functioning.
• Provides a non-narcotic, non-prescription alternative for sleep support.
• Minimizes next-day drowsiness when taken as directed 7-8 hours before arising.
• Supports circadian rhythm reset during periods of temporary sleep disruption.

Common use

Unisom SleepTabs are commonly used by adults for the short-term management of occasional insomnia, including difficulty falling asleep, frequent nighttime awakenings, or early morning awakening. It is particularly useful for individuals experiencing transient sleep disturbances due to stress, jet lag, shift work changes, or minor environmental disruptions. The product is intended for intermittent use rather than daily long-term administration, aligning with guidelines for over-the-counter sleep aids.

Dosage and direction

Adults and children 12 years of age and over: Take one tablet 30 minutes before bedtime. Swallow whole with water; do not crush, chew, or break the tablet. Use only once per 24-hour period. Ensure you have at least 7-8 hours available for sleep before needing to be active. Do not take more than one tablet in 24 hours. Not for use in children under 12 years unless directed by a doctor. Use for more than 2 weeks should only be done under medical supervision.

Precautions

Avoid alcohol consumption while taking this medication, as it may increase drowsiness and impairment. Exercise caution when driving, operating machinery, or performing activities requiring alertness the morning after use. Elderly patients may be more sensitive to the effects of antihistamines and should use extra caution. Those with breathing problems such as asthma, emphysema, or chronic bronchitis should consult a healthcare provider before use. Not recommended for use during pregnancy or breastfeeding without medical advice.

Contraindications

Do not use if you have known hypersensitivity to doxylamine succinate or any inactive ingredients in the formulation. Contraindicated in patients with narrow-angle glaucoma, severe hypertension, coronary artery disease, peptic ulcer, pyloroduodenal obstruction, or bladder neck obstruction. Should not be used by individuals taking monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOI treatment. Not for use in children under 12 years of age.

Possible side effects

Common side effects may include drowsiness, dizziness, dry mouth, nose or throat, blurred vision, and gastrointestinal discomfort. These effects are typically mild and often diminish with continued use. Less frequently, users may experience headache, restlessness, excitation, or nervousness, particularly in children. Rare but serious side effects include difficulty urinating, irregular heartbeat, severe dizziness, or confusion. Discontinue use and seek medical attention if severe reactions occur.

Drug interaction

Doxylamine succinate may interact with other central nervous system depressants including alcohol, sedatives, tranquilizers, barbiturates, and opioid pain medications, potentially enhancing sedation and impairment. Concurrent use with anticholinergic drugs may increase anticholinergic effects. May interact with medications metabolized by cytochrome P450 2D6. Consult a healthcare provider before use if taking prescription medications, particularly antidepressants, antipsychotics, or Parkinson’s disease medications.

Missed dose

Since Unisom SleepTabs are taken as needed for sleep, there is no scheduled dosing regimen. If you forget to take a dose at bedtime and cannot fall asleep, you may take one tablet if you still have at least 7-8 hours available for sleep. Do not take more than one tablet in 24 hours. Never double the dose to make up for a missed administration.

Overdose

In case of overdose, symptoms may include extreme drowsiness, confusion, agitation, nervousness, dry mouth, large pupils, flushing, fever, shaking, insomnia, hallucinations, or seizures. In severe cases, overdose may lead to respiratory depression, coma, or cardiovascular collapse. Seek immediate medical attention or contact a poison control center. Treatment is supportive and may include gastric lavage, activated charcoal, and symptomatic care.

Storage

Store at room temperature (68-77°F or 20-25°C) in a dry place protected from light and moisture. Keep the bottle tightly closed and out of reach of children and pets. Do not use if the blister pack is broken or tablets show signs of deterioration. Properly discard any unused medication after the expiration date printed on the packaging.

Disclaimer

This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. These statements have not been evaluated by the Food and Drug Administration. Consult with a healthcare professional before use if you have any medical conditions, take other medications, or if symptoms persist. Not for long-term use without medical supervision.

Reviews

Clinical studies demonstrate that doxylamine succinate significantly reduces sleep onset latency and improves sleep quality compared to placebo. User reviews frequently report effective sleep initiation with minimal next-day effects when used appropriately. Many users appreciate the non-habit forming nature of the medication and its availability without prescription. Some reports note that tolerance may develop with prolonged daily use, supporting recommendations for intermittent administration. Overall satisfaction rates are high for short-term management of occasional insomnia.