Xenical: Clinically Proven Weight Loss with Orlistat
Xenical
| Product dosage: 120mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
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| 120 | 1.95 $ | 772.20 $ 234.00 $ (70%) | 🛒 Add to cart |
| 180 | 1.75 $ | 1158.30 $ 315.90 $ (73%) | 🛒 Add to cart |
| 270 | 1.54 $ | 1737.45 $ 415.35 $ (76%) | 🛒 Add to cart |
| 360 | 1.30 $
Best per pill | 2316.60 $ 468.00 $ (80%) | 🛒 Add to cart |
| Product dosage: 60mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | 5.26 $ | 52.65 $ (0%) | 🛒 Add to cart |
| 20 | 2.92 $ | 105.30 $ 58.50 $ (44%) | 🛒 Add to cart |
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| 360 | 0.84 $
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Synonyms | |||
Xenical (orlistat) is a prescription medication specifically designed to aid in weight management for adults with obesity or overweight conditions, particularly when accompanied by risk factors such as hypertension, diabetes, or dyslipidemia. As a lipase inhibitor, it functions by blocking the absorption of approximately one-third of dietary fat intake, thereby creating a caloric deficit essential for sustainable weight reduction. Its efficacy is maximized when integrated into a comprehensive treatment plan that includes a reduced-calorie diet, regular physical activity, and behavioral modification. Endorsed by healthcare professionals globally, Xenical represents a scientifically validated pharmacological approach to combating obesity, offering a mechanism of action distinct from appetite suppressants or central nervous system stimulants.
Features
- Contains orlistat 120 mg as the active pharmaceutical ingredient
- Functions as a gastrointestinal lipase inhibitor, blocking fat absorption
- Requires prescription and medical supervision for appropriate use
- Manufactured under strict pharmaceutical quality control standards
- Available in capsule form for oral administration
- Designed for use in conjunction with a medically supervised low-calorie diet
Benefits
- Promotes clinically significant weight loss when combined with lifestyle modifications
- Reduces absorption of dietary fats by approximately 30%, aiding caloric deficit creation
- Improves obesity-related comorbidities including glycemic control in type 2 diabetes
- Lowers LDL cholesterol and total cholesterol levels through reduced fat absorption
- Provides a non-systemic mechanism of action with minimal central nervous system effects
- Supports long-term weight maintenance when used as part of comprehensive obesity management
Common use
Xenical is indicated for obesity management in adults with a body mass index (BMI) of 30 kg/m² or greater, or 27 kg/m² or greater in the presence of other risk factors such as hypertension, type 2 diabetes, or dyslipidemia. It is utilized as an adjunct to a reduced-calorie diet and increased physical activity. Treatment is typically initiated after appropriate medical evaluation confirms that non-pharmacological approaches have yielded insufficient weight loss. The medication is commonly prescribed for chronic weight management rather than short-term use, with treatment duration determined based on individual response and continued medical necessity.
Dosage and direction
The recommended dosage of Xenical is one 120 mg capsule taken three times daily with each main meal containing fat. Administration should occur during the meal or up to one hour after eating. If a meal is missed or contains no fat, the dose of Xenical should be omitted. The capsule should be swallowed whole with water and not crushed, chewed, or divided. Maximum daily intake should not exceed three capsules. Dosage adjustment is not required for elderly patients or those with hepatic impairment, but renal impairment requires careful consideration and possible dosage modification.
Precautions
Patients should maintain a nutritionally balanced, reduced-calorie diet containing approximately 30% of calories from fat to minimize gastrointestinal adverse effects and ensure adequate nutrient absorption. Distributed fat intake equally across three main meals is recommended. Supplemental multivitamins containing fat-soluble vitamins (A, D, E, K) should be taken once daily at least 2 hours before or after Xenical administration to prevent reduced vitamin absorption. Regular monitoring of weight, BMI, and obesity-related parameters is essential. Patients should be advised regarding the potential for gastrointestinal events and appropriate management strategies.
Contraindications
Xenical is contraindicated in patients with chronic malabsorption syndrome or cholestasis. It should not be used during pregnancy or breastfeeding unless clearly necessary and under strict medical supervision. Hypersensitivity to orlistat or any component of the formulation prohibits use. The medication is not recommended for patients undergoing organ transplantation or those taking cyclosporine due to interaction risks. Those with history of hyperoxaluria or calcium oxalate nephrolithiasis should avoid Xenical due to increased risk of renal stone formation.
Possible side effects
Common adverse effects primarily involve the gastrointestinal system and include oily spotting, flatus with discharge, fecal urgency, fatty/oily stool, oily evacuation, increased defecation, and fecal incontinence. These effects are generally mild to moderate, decrease with continued use, and are associated with high-fat meals. Other reported effects include abdominal pain/discomfort, nausea, vomiting, and headache. Rare but serious side effects may include hepatotoxicity, hypothyroidism, oxalate nephropathy, and pancreatitis. Patients should report any unusual symptoms, particularly jaundice, pruritus, or dark urine.
Drug interaction
Xenical may reduce absorption of fat-soluble vitamins and beta-carotene, necessitating vitamin supplementation taken at least 2 hours apart. It can decrease plasma concentrations of cyclosporine, amiodarone, anticonvulsants, levothyroxine, and oral contraffective, requiring monitoring and possible dosage adjustments. Concurrent use with acarbose is not recommended. Xenical may affect INR levels in patients taking warfarin, requiring close monitoring. It does not interact with alcohol, digoxin, phenytoin, oral contraceptives, or nifedipine in clinically significant ways.
Missed dose
If a dose is missed, it should be skipped and the regular dosing schedule resumed with the next meal. Patients should not take a double dose to make up for a missed administration. Consistent adherence to the prescribed dosing regimen with meals containing fat is important for optimal efficacy. If multiple doses are missed, patients should consult their healthcare provider rather than attempting to compensate with increased dosing.
Overdose
Cases of overdose have reported with doses up to 800 mg daily without serious adverse effects. Management should focus on symptomatic treatment and supportive care. Given the medication’s local action within the gastrointestinal tract, systemic effects are unlikely. Patients experiencing overdose may exhibit increased gastrointestinal symptoms such as abdominal discomfort, nausea, and oily discharge. Medical attention should be sought for appropriate evaluation and management, though serious consequences are uncommon.
Storage
Store Xenical capsules at room temperature between 15-30°C (59-86°F) in their original container. Protect from moisture and light. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Proper disposal of unused medication should follow local regulations, typically through medication take-back programs rather than flushing or household trash.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Xenical is a prescription medication that should be used only under the supervision of a qualified healthcare professional. Individual results may vary, and not all patients will experience the same benefits or side effects. Patients should consult their healthcare provider for personalized medical advice, including assessment of appropriate use, dosing, and monitoring based on their specific health status and medical history.
Reviews
Clinical studies demonstrate that Xenical produces average weight loss of 5-10% of initial body weight when combined with lifestyle modification over one year. Patients report satisfaction with measurable results though note the necessity of dietary compliance to minimize gastrointestinal effects. Healthcare professionals appreciate its mechanism of action and evidence-based efficacy while emphasizing the importance of comprehensive weight management programs. Long-term users report sustained weight maintenance when combined with ongoing lifestyle modifications.