
Flagyl ER
Product dosage: 200mg | |||
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Flagyl ER: Effective Extended-Release Bacterial Infection Treatment
Flagyl ER (metronidazole extended-release) is a prescription antibiotic and antiprotozoal medication designed to combat a range of serious bacterial and parasitic infections in the gastrointestinal system and beyond. Its advanced extended-release formulation ensures sustained therapeutic levels in the body, enhancing efficacy while potentially improving dosing convenience. It is specifically indicated for use in adults and should be used under strict medical supervision to ensure optimal outcomes and minimize risks.
Features
- Active ingredient: Metronidazole 750 mg
- Formulation: Extended-release tablet
- Administration: Oral
- FDA-approved for specific bacterial and protozoal infections
- Designed for once-daily dosing to maintain consistent plasma concentrations
- Coated tablet to facilitate swallowing and control drug release
Benefits
- Provides sustained antibiotic action, effectively eradicating susceptible anaerobic bacteria and certain parasites.
- Reduces dosing frequency to once daily, potentially improving patient adherence to treatment regimens.
- Minimizes peak-trough fluctuations in drug levels, supporting more consistent therapeutic effects.
- Targets infections directly in the gastrointestinal tract and other anaerobic environments.
- Helps prevent recurrence of infection when used as directed under medical supervision.
- Supported by extensive clinical data demonstrating efficacy in approved indications.
Common use
Flagyl ER is commonly prescribed for the treatment of bacterial vaginosis in adult women. It is also used for other infections caused by susceptible anaerobic microorganisms, including intra-abdominal infections, skin and skin structure infections, gynecologic infections, and certain protozoal infections such as amebiasis and trichomoniasis. Its use should be based on confirmed diagnosis and susceptibility testing where appropriate.
Dosage and direction
The typical dosage for Flagyl ER is one 750 mg tablet taken orally once daily, preferably with food to minimize gastrointestinal upset. The duration of treatment varies based on the infection being treated: usually 7 days for bacterial vaginosis, and as determined by the physician for other indications. Tablets should be swallowed whole and not crushed, chewed, or split. Complete the full course of therapy even if symptoms improve earlier, unless directed otherwise by a healthcare provider.
Precautions
- Avoid alcohol consumption during treatment and for at least 3 days after completion due to risk of disulfiram-like reaction (nausea, vomiting, flushing, tachycardia).
- Use with caution in patients with central or peripheral nervous system disorders; metronidazole has been associated with neurologic adverse effects.
- Monitor for signs of superinfection or opportunistic pathogens.
- Not recommended during the first trimester of pregnancy; use in later trimesters only if clearly needed.
- Hepatic impairment may require dosage adjustment or avoidance; monitor liver function.
- May cause dizziness or drowsiness; patients should avoid driving or operating machinery until response is known.
Contraindications
- Hypersensitivity to metronidazole, other nitroimidazole derivatives, or any component of the formulation.
- History of prior metronidazole-associated blood dyscrasias.
- Concurrent use with disulfiram or within 2 weeks of disulfiram therapy.
- Use during the first trimester of pregnancy for trichomoniasis treatment (relative contraindication; consider risk-benefit).
Possible side effect
Common side effects may include nausea, headache, dry mouth, metallic taste, anorexia, vomiting, and diarrhea. Less frequently, patients may experience dizziness, constipation, abdominal discomfort, or furry tongue. Serious side effects can include peripheral neuropathy, seizures, encephalopathy, leukopenia, pancreatitis, and hypersensitivity reactions. Discontinue and seek medical attention if severe reactions occur.
Drug interaction
- Alcohol: Risk of disulfiram-like reaction.
- Warfarin: Metronidazole may potentiate anticoagulant effect; monitor INR.
- Lithium: Possible increased lithium levels and toxicity.
- Cyclosporine: Potential increase in cyclosporine levels.
- Phenytoin, phenobarbital: May reduce metronidazole efficacy.
- Cimetidine: Can increase metronidazole plasma concentrations.
- Disulfiram: Concurrent use contraindicated.
Missed dose
If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to catch up. Resume the regular dosing schedule. Consult a healthcare provider if unsure.
Overdose
Symptoms may include nausea, vomiting, ataxia, seizures, and peripheral neuropathy. There is no specific antidote. Treatment is supportive and symptomatic, including gastric lavage if recent ingestion. Hemodialysis may accelerate elimination. Contact a poison control center or seek emergency medical attention immediately.
Storage
Store at room temperature (20–25°C or 68–77°F), in a dry place, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here.
Reviews
Clinical studies and patient reports generally indicate that Flagyl ER is effective in treating indicated infections, with the extended-release formulation offering convenience and tolerability for many users. Some patients note gastrointestinal side effects, though these are often manageable with food co-administration. Adherence to avoidance of alcohol is frequently emphasized in user experiences to prevent adverse reactions. Always consult with a healthcare professional for personalized assessment and treatment.